Today in Cell we report evidence for a covalent linkage between small RNAs and N-glycans via acp3U Work by Yixuan (Axe) Xie Peiyuan Chai +collab w/Ben Garcia | HSCRB Excited to accelerate more work related to glycoRNAs in many new contexts. doi.org/10.1016/j.cell…

Spread the word, we are looking to hire a new lab manager ⁦HHMI⁩ ⁦Sarafan ChEM-H⁩ hhmi.wd1.myworkdayjobs.com/en-US/External…

1/ I did my own little hackathon last weekend designing EGFR binders for Adaptyv Bio's protein design competition. I was really excited to see that my submissions took the top 10 spots in the virtual scoring phase! I got some DMs asking about my process so here's a thread:

Just to save some of you the trouble: It reads: "Candidates applying for a position at the Assistant Professor level are expected to have K99/R00 grants or equivalent and develop a rigorous extramurally funded research program."

This is one of the more interesting articles I have read this year: the former dean of Harvard Medical School had a start-up in the late 1980s based on using GLP1s to treat diabetes and weight loss, but Pfizer stopped funding it despite promising early results. Two lessons:

You have 3 coins. 2 of them are fair; one is rigged so that it always lands on heads. You choose a coin at random and flip it; it lands on heads. The coin is probably

See--they don't all require a K99!! "Successful candidates will be provided laboratory and office space at the Medical School along with a competitive start-up package to develop a robust research program." 1/2

These proteins all have the same molecular weight. In fact they all have the same amino acid composition

Spread the word, the Innovative Medicines Accelerator ⁦Stanford Medicine⁩ ⁦Sarafan ChEM-H⁩ is searching for a Director of Computational Drug Discovery, please repost! Director of Computational Drug Discovery - Stanford University Careers careersearch.stanford.edu/jobs/director-…

6 main figs and 5 supplementary figs .

Ok who has tips for taking parental leave as a PI, specifically for lab management? (Pls rt)

I’m overjoyed to announce that my K99/R00 proposal has been funded by The National Institute on Aging (NIA) as of today!! I am very excited about the project which is a collaboration with Lehtinen Lab to study the blood-CSF barrier with new analytical tools I’ve developed in the Gygi Lab. Feeling grateful!!

Nice piece by Derek Lowe on back to back papers by ⁦Vicki Wysocki⁩ and ⁦AstburyBiostructure⁩ ⁦ACS Central Science⁩ New Mass Spec Frontiers | Science | AAAS science.org/content/blog-p…

Happy birthday to proteomics! I guess I’d better pick up a cake or something to celebrate….

What an amazing way to start the lab! We cant wait to uncover more mechanisms of oligodendrocyte and myelin plasticity and learn how it impacts cognitive aging. More details in our website - weizmann.ac.il/molneuro/iram/ DM or email me if you are interested to join the team! #ERCStG

I... did not expect this to be this close

Our #FragPipe-Analyst manuscript is out! pubs.acs.org/doi/10.1021/ac…. Load FragPipe's TMT/ LFQ/DIA quant tables (peptide or protein quant) and get QC, Limma, PCA, volcano plots, heatmaps, do GO/pathway enrichment analysis, all with just a few clicks! Tutorials:fragpipe-analyst-doc.nesvilab.org

when you made a small mess in the lab and then see the "hey everyone, just a friendly reminder ..." email

Excited our final version of Christine Isadora Ng's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. Sarafan ChEM-H Stanford Chemistry nature.com/articles/s4158…