#LongCovid is complex to diagnose and treat, so we need #biomarkers ! 1. to confirm viral persistence, and 2. to map the failing/overactive immune response. So we tried to hit two birds with one stone using digital transcriptomics 👇👇 (1/n)
thelancet.com/journals/lanmi…

The #SARSCoV2 viral RNA signature in people with #LongCovid markedly differs vs controls
thelancet.com/journals/lanmi… The Lancet Microbe
Also linked to symptoms.
Not only indicative of persistence, but also potential as a biomarker Johan Van Weyenbergh marc jamoulle KU Leuven

Exploring the #genomic architecture of circulating #cytokines in the largest to-date dataset of 75,000 individuals, we find

👉169 loci associated with cytokine levels
👉 promising drug targets for immune-mediated diseases

Check out for more:
medrxiv.org/content/10.110…

📰 Mitral regurgitation in heart failure with preserved ejection fraction: The interplay of valve, ventricle, and atrium.

Read out latest review in #EJHF 🧵

onlinelibrary.wiley.com/doi/10.1002/ej…

Lucky to play a small role in this cool story from Jason Roh Claire Castro Anthony Rosenzweig, MD MGH Cardiovascular Research Center

The placenta has a 9-mo lifespan 🤰

Jason & Claire find that placental aging can ➡️ maternal 🫀 dysfunction, w/ intriguing potential Rx implications

science.org/doi/10.1126/sc…

📢 #Europace #EPeeps
Crucial real-world validation of smartphone-based photoplethysmography for rate and rhythm monitoring in AF patients.

This #PPG algorithm has a positive predictive value of 99.6% for AF detection. 🎯 #ECG

academic.oup.com/europace/artic…

We studied the association of CHIP and AF and investigated the potential intermediates.

jamanetwork.com/journals/jamac…

Mohammadreza Naderian M Mesbah Uddin Ozan Dikilitaş, M.D. Art Schuermans Liz Selvin vijay nambi Alex Bick Michael Honigberg, MD, MPP Na Li (李娜) Lab Pradeep Natarajan Iftikhar J. Kullo Christie Ballantyne

Good to see that this is finally out! A full thread is loading

Results of this cohort study show that large TET2 and ASXL1 CHIP—but not DNMT3A CHIP—were associated with higher IL-6 level, indices of cardiac remodeling, and an increased risk for AF. ja.ma/3VOzLAf

New work led by Mohammad Saadatagah Mohammadreza Naderian in JAMA Cardiology underscores that not all CHIP 🩸🧬 is the same. TET2 CHIP assoc'd w/ ⬆️ IL-6 and AF risk, esp when clones are large.

jamanetwork.com/journals/jamac…

Art Schuermans Alex Bick Pradeep Natarajan Iftikhar J. Kullo Christie Ballantyne

People around the word are living to older ages.

Understanding the aging heart is key to improving the 'healthspan'

How can we best capture biological aging of the heart?

We review key concepts, established and emerging methods:

doi.org/10.1016/j.jcmg…

#healthyaging #MedEd

Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System.
Published in JACC IMAGING ➡️ doi.org/10.1016/j.jcmg…
🙏 to Zahra Raisi-Estabragh & Steffen Petersen for involving me in CMRs role in tracking Ageing. JACC Journals EACVI President American College of Cardiology
BSCMR BSEcho

Our article to get you up to speed on tracking heart aging via noninvasive imaging at JACC Journals!

Delighted to contribute to this review led by Zahra Raisi-Estabragh on imaging and other biomarkers for tracking biological aging of the cardiovascular system JACC Journals #JACCCVI jacc.org/doi/10.1016/j.…

Be sure to read the section on the role of “big data” in understanding aging 😉

Christian Faaborg Andersen MD MGH IM Residents presenting data on trends/disparities in Lp(a) testing 🧪 in the MGB system from 2000-present at #ACC24 American College of Cardiology
▪️Testing rates low across the study period but ⬆️ing since 2020
▪️Women and Black patients less likely to be tested
Paper coming soon!

Please join us April 11 Thurs 10-11am EDT for #HypHIP Hypertension livechat on cumulative DBP burden-MACE in Mass General Brigham Mass General Heart cohort! Pradeep Natarajan Broad Institute CGM at MGH MGH Cardiovascular Research Center

Exercise Echocardiography for mPAP/CO Slope Estimation: A New Standard for Routine Clinical Care?

Yes! and...
Agitated colloid makes it so much easier!

📎 doi.org/10.1016/j.jacc…

Jan Verwerft Guido Claessen

Come catch a discussion of #SouthAsianCVD at #ACC24 on Monday April 8th from 12:45p-2p Excited to discuss with
Anandita Agarwala Kulkarni, MD FACC Dinesh Kalra, MD Jaideep Salim Virani Aarti M Thakkar and others!

Catch us there!
OurHealth Pradeep Natarajan Douglas Drachman Ami Bhatt, MD

Upcoming issue of #cardiorenal medicine with guest editor Amir Kazory discusses some #cardiorenal controversies.

Together with Jef Van den Eynde reviewed 'Sodium Avidity in Heart Failure', for physiology fans...

karger.com/crm/article/do…

Now online at Hypertension
👇
ahajournals.org/doi/10.1161/HY…

This pilot study was a true 'labor of love' (no pun intended) that we hope will lead to larger studies - still much we don't understand about 🫀 effects of 🤰

🧵 of primary findings attached 👇

(1 / 2)