Happy #WorldPhageDay start of the #WorldPhageWeek! Watch this catchy testimonial about #phage #therapy recorded by our L.A.B. members Célia Pas Dimi Boeckaerts #antibioticresistance #AMR FWO Faculty of Bioscience Engineering UGent UGent Superbugs & Phage therapy youtu.be/XhF1-KGH1bI

Our new opinion piece on predicting #phage infectivity with #MachineLearning is out! A thread with some key points below 👇 or read the full article here: authors.elsevier.com/c/1eHhT6hO9tQJ…

I've been working with awesome people (Jody Mou Brian L Trippe Ava Soleimany Alex Lu Lucy Colwell) to put this together. I'm really excited for the first 4 speakers we have lined up and look forward to hearing about and discussing cool research. ml4proteinengineering.com

Video of Bruce's talk: Machine Learning-Assisted Protein Engineering with ftMLDE and evSeq youtu.be/hae6IpcDCc0

Bjorn Criel from UGent discussed machine learning-guided #engineering of modular #enzybiotics to target Enterococcus faecalis infections of the urinary tract. They created PhaLP, a database of phage lytic proteins, that helps facilitate development of new modular enzybiotics.

Some of the BSVOM members shining on our first day at @VoM_2022 yesterday! Ready fo day 2! Come say hi :)

Frank Oechslin addresses the biological relevance of the diversity of phage endolysins. Using CRISPR, exchanged endolyins between phages. Across different phages, endolysins coming from different phages lead to fitness costs manifesting by smaller plaques. #vom2022

Full house for the PhaLP.org workshop by Bjorn Criel on the database for phage lysin research @VoM_2022 Did you miss it? Watch youtu.be/vLChUjGe5LM

It was a great experience to introduce the PhaLP database to the phage lysin community at @VoM_2022. Thanks to the organisers of this fantastic conference for the opportunity!

Group photo of the BSVoM members present at the @VoM_2022 conference! 😃 Great last day of the conference here in Guimaraēs!

Today in partnership with EMBL-EBI, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: dpmd.ai/AF-22-TW 1/

Bacteriophages produce endolysins to degrade host cell walls & release new particles. Sylvain Moineau &co use #CRISPR to shed light on #bacteriophage endolysin diversity, phage-bacteria interactions & #endolysin adaptation to a new bacterial host #PLOSBiology plos.io/3Jv0Gc3

Since the # of "[α-ω](fold){0,1}[A-z]*" tools are getting out of hand, I tried to curate a lil list of the ones I'm aware of: github.com/sacdallago/fol… Peeps w/ overview Sergey Ovchinnikov Martin Steinegger 🇺🇦 Kevin K. Yang 楊凱筌 feel free to contribute if I missed stuff?

BREAKING: White House issues new policy that will require, by 2026, all federally-funded research results to be freely available to public without delay, ending longstanding ability of journals to paywall results for up to 1 year. Coverage coming on ScienceInsider.

So what happens when you replace BLAST/MMseqs2 with embedding/language model based search? The latest generation of protein language models (ProtT5/ESM) is really good at remote homology, but there are also a bunch of catches

I am thrilled to announce the launch of our new spinoff, obulytix.com! Obulytix is developing a revolutionary solution for antibiotic resistance based on #phage #lysins UGent KU Leuven Bjorn Criel Dennis Grimon Maria Fonseca news.turnstone.be/t/i-43FC032300…

Vlaamse start-up werkt aan nieuwe generatie antibiotica: ‘Als dit lukt, kunnen we honderdduizenden levens per jaar redden’ tijd.be/ondernemen/far…