Have you ever wondered why there are so many subtypes of immune cells? In our work published today at nature, we offer one possible reason – the capacity to evolve. 1/n nature.com/articles/s4158…

📢New preprint alert: #Benchmarking second-generation methods for cell-type #deconvolution of #transcriptomic data doi.org/10.1101/2024.0… A thread 🧵👇 1/

How many academic papers are written with the help of ChatGPT? To answer this question, we analyzed 14mln PubMed abstracts from 2010 to 2024 and looked for excess words: ** Delving into ChatGPT usage in academic writing through excess vocabulary ** arxiv.org/abs/2406.07016 1/11

JAKing up immunity | Science science.org/doi/10.1126/sc…

‼️Must read review by Miki De Palma EPFL Life Sciences and Doug Hanahan Ludwig Cancer at Nature Cancer nature.com/articles/s4301… Tumor blood vessels ARE important‼️

Circulating KLRG1+ memory T cells rapidly enter nonlymphoid tissues after viral infection and differentiate into resident memory Science Immunology Hamilton Hart Lab science.org/doi/10.1126/sc…

rdcu.be/dMdQ9   Excited and proud to see the final version of our manuscript out Nature Communications, describing a new lipid droplet reporter mouse, which allows staining-free fluorescent visualization of #LipidDroplets!! Check out how numerous they are in the brain!

New paper from the lab lead by Anthony Bertrand identifies impact of social economic status on healthy immune responses in Milieu Intérieur ICB - the journal onlinelibrary.wiley.com/doi/10.1111/im…

Happy to share our new NK cell resource in Nature Immunology: "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping." nature.com/articles/s4159…. Herman K. Netskar, Aline Pfefferle, Horowitz Lab @Icahn School of Medicine Mount Sinai Human Cell Atlas, Precision Immunotherapy Alliance, UiO - Det medisinske fakultet

Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity: Cell Reports Medicine cell.com/cell-reports-m…

Our multimodal model to combine TCR sequences with scRNA-seq is finally out. The most interesting part for me was observing a clear case where the combination of TCR sequence and cell state (RNA) preserved both clonotype and cell type information, leading to a more holistic cell

A very nice perspective on MDSCs … still not sure what they are! nature.com/articles/s4157…

Excellent work from Gabrielle Campanella, Thomas J. Fuchs Icahn School of Medicine at Mount Sinai! Benchmarking 8 pathology foundation models including UNI, Virchow and Prov-GigaPath on large scale datasets for clinical diagnosis and biomarker discovery and providing insights into data scaling laws and

Exciting results from Stanford Medicine showing >50% CR in adult patients treated with CD22 CAR T who previously relapsed after CD19 CAR T therapy. Importantly, "of the 20 patients with a complete response after receiving CAR22, only three (15%) patients relapsed"

1/6 Introducing MultiMIL: a weekly supervised multimodal model to identify disease-specific changes in single-cell atlases. Using a multiple-instance learning framework and attention mechanism, it prioritizes cells linked to various phenotypes in a large single-cell reference

🙌🧬It’s official: the first TCR gene therapy for the treatment of cancer received U.S. FDA approval this evening. A milestone event for the oncology community and the 2nd cell therapy approved for solid cancers! Adaptimmune #Tcellpower adaptimmune.com/investors-and-…

Mapping myeloid cell function: Spatial diversity in tumor and neuronal microenvironment cell.com/cancer-cell/ab…

Paper 🚨! Ecstatic, proud, grateful …Years of dedication from the whole lab, with the exceptional Daan J. Kloosterman and the one of a kind #JohannaErbani at its helm. What a journey all the way to Cell! How did it start (& end)? A 🧵1/n cell.com/cell/fulltext/…

Our latest paper is out in nature! Hair follicle stem cells activate phagocytosis to clear apoptotic neighbours and maintain homeostasis👇🏼 Shout-out to Katie Stewart and everyone involded for the great work 👏🏼 nature.com/articles/s4158…

Major effort from the lab (💪Robert Frömel), finally on biorxiv: We built 60,000 fully synthetic enhancers and measured their cell state specific activity during blood stem cell differentiation. Why did we do that and what did we learn🧵? biorxiv.org/content/10.110…