Happy to share a publication from the lab demonstrating that 53BP1 loss is a positive predictive biomarker for immune checkpoint blockade efficacy, with important implications for the treatment of PARPi-resistant ovarian and pancreatic cancers! nature.com/articles/s4146…

Curious about the mechanisms of replication fork reversal? Our review highlighting the current models of this pathway is out now sciencedirect.com/science/articl…

Some new updates for upcoming international DNA damage and repair conferences: docs.google.com/spreadsheets/d…

Having a hard time with #CRISPR HDR? Your cells might be fighting against you! TREX1 nuclease, high in some cells, eats up HDR donor templates. Check out our paper in Nature Biotechnology for the story & ways to improve HDR. nature.com/articles/s4158… With Erman KARASU & John Maciejowski

Very interesting paper from the Karlene Cimprich lab and collaborators, showing that HLTF removes G4 structures, using a very different mechanism from other proteins characterized to date. Thanks for having us on board! sciencedirect.com/science/articl…

Very happy to announce the publication of our paper on the human Shu complex and its role modulating RAD51 and RPA function in Nature Communications today Tufts Biology Department ! nature.com/articles/s4146…

Excited for our pub. in Nature Communications, Human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA, Congrats to ⁦Sarah R. Hengel Ph.D.⁩ ⁦Ben Van Houten⁩ ⁦Chelsea⁩ ⁦Maria Spies, PhD (she/her)⁩ ⁦Matt Schaich⁩ et al nature.com/articles/s4146…

🚨 Excited to share our latest paper in Cell identifying how under-replicated chromosomes in micronuclei become shattered by the Fanconi anemia pathway during mitosis. This work was led by UTSW Graduate School of Biomedical Sciences student Justin Engel. 🧵 (1/13): cell.com/cell/fulltext/…

Huge advance in making transplantable hematopoetic stem cells in vitro from iPSC – with efficiencies similar to umbilical cord blood transplantation. I love that Aussies are leaders in this technology, that could revolutionise bone marrow transplantation. nature.com/articles/s4158…

Excited to share our lab's latest research, out today NatureStructMolBiol, which describes how 53BP1 controls DNA Repair in class-switching B cells & BRCA1 mutant cancers. Final article can be found here: nature.com/articles/s4159…; & the following thread walks you through the details

A fantastic lineup of speakers for the "Machines acting on DNA and RNA" meeting at CNIO Stop Cancer All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬 May 28th to 30th, 2025 - Save the date! Oscar Llorca Rafa F Leiro 🍍 The Nogales Lab

We are thrilled to present you our work on BRCA1-BARD1 nature showing that the complex has a direct role in long-range DNA end resection. With Ilaria_Ceppi Maria Rosaria Dello Stritto and our collaborators Pablo Huertas' Lab Sylvie Noordermeer and Seidel labs. nature.com/articles/s4158…

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…