So proud of Yi Hao again! 😀 Check his second post-doc paper here! 😀

Two kids with HSV-1 encephalitis were found by Casanova Lab to have rare mutations that indirectly allowed the virus to enter their brain cells, demonstrating how protein deficiencies and mutations can facilitate brain inflammation via viral infection. nature.com/articles/s4158…

TMEFF1 as a neuron-specific restriction factor essential for prevention of HSV-1 replication in the central nervous system nature #Cai #Paludan Yi-Hao Chan Lab Shen-Ying Zhang Casanova Lab #Bastard #Studer nature.com/articles/s4158…

Huge congrats to Yi-Hao Chan Lab, Zhiyong Liu, Paul Bastard, Shen-Ying Zhang, Lorenz, Casanova Lab and all co-authors for the exciting study in nature describing human TMEFF1 as an HSV-1 restriction factor in the brain. Happy to have played a small role. Excellent thread below 👇

A novel disease-causing gene of herpes simplex encephalitis ( #HSE ): #TMEFF1, which inhibits the neurological entry of HSV-1 via interacting NECTIN-1 (a key HSV-1 receptor). Thrilled to have contributed to this amazing work!

Excited to see the work published nature. Excellent summary in thread below. Big collaborative effort with Shen-Ying Zhang, Casanova Lab + many more. Special thanks to Yi-Hao Chan Lab, Zhiyong Liu, Paul Bastard and in my lab Noopur Khobrekar, Param Amin, Gabriele Ciceri & Oliver Harschnitz

Nature research paper: Human TMEFF1 is a restriction factor for herpes simplex virus in the brain go.nature.com/3ShfVL9

Hearty congratulations to Yi-Hao Chan Lab, Zhiyong Liu, Shen-Ying Zhang and the team for identifying TMEFF1 as a novel HSV-1 restriction factor. Always such an awe-inspiring science in our collaboration with the Casanova Lab.

It was great experience to bring this story to publication with the wonderful multidisciplinary team, and, the reviewers and editors JExpMed . Thank you!

An excellent blog post.

This is too bad. Please also do keep in mind that being positive for autoantibodies to type I IFNs in blood is a major risk factor of developing encephalitis upon infection by West Nile virus. DOI: 10.1084/jem.20230661

Qu'est-ce que le virus de l'encéphalite équine de l'Est ? Qu'est-ce que cela signifie pour nous au Québec ? Mes 💭avec Pauline Gravel Le Devoir 👇🏽 Le virus de l’encéphalite équine de l’Est sur le radar de la Santé publique ledevoir.com/societe/scienc…

Amazing!! What a pleasant surprise to be featured on the cover of JExpMed! (: please read our paper in collaboration with #CHGE here: dx.doi.org/10.1084/jem.20…

Glad that this story made the cover JExpMed :-)

Great thread on post-vaccine myocarditis and the clinical outcomes. Those with myocarditis post vaccine had on average less cardiovascular complications compared to those with myocarditis following infection. But it was not 0. 👏 to authors

Premier cas humain du virus du Nil occidental confirmé dans l'Hérault après plusieurs décès équins. Les acteurs concernés se mobilisent pour mener des recherches sur la circulation de ce virus notamment au sein de ses réservoirs aviaires et des moustiques francetvinfo.fr/sante/maladie/…