Exciting opportunity to become #TeamIHB 's Scientific Operations Director! Help us drive IHB’s positioning in the scientific community and ensure the operational efficiency of the institute and its integration within the Roche ecosystem. Pls RT & details at bit.ly/ihbopsdir

Tomorrow is the deadline for faculty applications at Sloan Kettering (facultysearch.ski.edu). For applicants interested in the Center for Stem Cell Biology, we are linked closely with the Developmental Biology Program search bit.ly/3txx21V

Preprint led by Chao Zhang Nathalie Saurat Doron Betel on a strategy for measuring/manipulating cellular age bit.ly/3KIJ7XI. “RNAge” is used to track induced aging strategies in iPSC human neurons & to perform in silico screen for identifying novel aging & rejuvenation compounds

Check out our new exciting Cell Stem Cell paper that shows microglia replacement can restore Trem2 function in a mouse AD model. Congratulations Yongjin Yongjin Yoo and the other contributors from the lab!
cell.com/cell-stem-cell…

Excited to share initial press release BlueRock Therapeutics on promising results of Phase 1 trial in 12 PD patients bit.ly/3JCKneG. A major milestone on a 20+ year journey. Amazing leadership by Viviane Tabar, Memorial Sloan Kettering Cancer Center & BlueRock Therapeutics (@bigosi, Mark Tomishima & many more).

Really enjoyed the meeting #StemCellNiche2023 . Also – an interesting experience to see your talk (and yourself!) being converted in real-time into an artistic illustration.

Visionary effort from Roche Hans Clevers & Matthias Lutolf to push the frontiers in organoid research Institute of Human Biology. At interface of fundamental discoveries, human translation, drug discovery & precision medicine. This will be a very exciting place to make true progress!

Excited to see this finally published. Thanks to Homa Majd & Faranak Fattahi lab for pushing it over finish line after MANY(!) years. An unexpected role for Schwann cells in diabetic neuropathy and for atypical antidepressant (Bupropion) in potentially preventing/treating it.

Another piece in the puzzle on the genetic causes of HSV-1 encephalitis, involving impaired cell death. Great collaboration with Casanova Lab Shen-Ying Zhang and many others. Special thanks to Oliver Harschnitz Noopur Khobrekar and Param Amin from my lab involved in the RIPK3 project.

Happy to share our newest study on bioRxiv. „Suppression of #ferroptosis by vitamin A or antioxidants is essential for neuronal development.“ biorxiv.org/content/10.110…
Fantastic team effort. Michelle Vincendeau Kamyar Hadian Michael Menden Brent Stockwell Lorenz Ferroptosis

The identification of a key role for TNFa-NFkB signaling in limiting cell survival of hPSC-derives dopamine neurons upon transplantation. Congrats to Taewan Kim, So Yeon Koo, and the rest of the Lorenz lab on this exciting work!

Why and when do grafted neurons die? Preprint by Taewan Kim So Yeon Koo from lab & collab. uses in vivo CRISPR screen to identify TNFa-NFkB-p53 loop restricting hPSC-DA neuron survival, and offers clinically relevant solution Center for Stem Cell Biology at Sloan Kettering Memorial Sloan Kettering Cancer Center bit.ly/3nJhp4o

Kicking off a great ride ⁦Cycle for Survival⁩ this morning ⁦Memorial Sloan Kettering Cancer Center⁩ ⁦Equinox⁩ with my lab team! Thanks for ALL the donors and participants ⁦Neurosurgery at Memorial Sloan Kettering⁩

Very interesting story in BioRxiv from Faranak Fattahi lab on Schwann cell vs early NC-derived melanocytes.

In vivo gut motility controlled by grafted human PSC-derived ENS in severe mouse model of Hirschsprung’s disease. Study now published Cell Stem Cell on sacral-derived ENS precursors bit.ly/3J8EoOA. Huge effort by Yujie Fan and an amazing team of collaborators Center for Stem Cell Biology at Sloan Kettering

Nice in preprint Development discussing human neuronal maturation timing. Lorenz Pierre Vanderhaeghen. Thank you Teresa Rayon Jelle van den Ameele Development

Precise #GeneEditing can be arduous in #hPSCs but Drs. Lorenz, Ting Zhou, and team from Memorial Sloan Kettering Cancer Center found a way to increase the efficiency.

They applied PE3 with p53DD to efficiently create multiple isogenic hPSC lines.

More in Nature Communications | 📖 go.nature.com/3T0v5SU

My lab Center for Stem Cell Biology at Sloan Kettering Memorial Sloan Kettering Cancer Center is looking to recruit a postdoctoral fellow to work on an exciting, large-scale collaborative project with Dr. Danwei Huangfu Lorenz labs (NHGRI MORPHIC initiative)

genome.gov/research-fundi…

Congratulations to Arianna Baggiolini. What a great start to independence and extremely well deserved!