Wonderful talk on AST for NTM

Have been using linezolid quite a lot for M.abscessus but surprised to know that it doesn't seem to be a good agent according to its breakpoint and PK/PD

Wonder how is everyone's experience/thought about this?

#ESCMIDGlobal2024

For SAB at high risk of deep-seated or metastatic infections, 14 days of antibiotics (rather than longer) should be given if:
➡️detailed diagnostic evaluation (e.g. TEE, PETCT) is negative
➡️No non-removable cardiac device/vascular graft/DVT at catheter site

#ESCMIDGlobal2024

Happy to have joined my first ever #IDtwitter meet up last night 😊

#ESCMIDGlobal2024

Hola~

#ECCMID2024

Severe gastritis with yellowish exudates after taking an antibiotic

Guess what's the culprit?

Echinocandins for urinary tract infections

Your thoughts?

Ilan Schwartz MD PhD Neil Stone Andrej Spec, MD, MSCI

Degradation pattern for each type of β-lactamase

doi.org/10.3390%2Fanti…

This is a case of NDM E.coli

The 💊 of choice is a combo of the apparently R ceftazidime-avibactam + aztreonam (if synergy confirmed)

Tigecycline, despite S, is not a good choice by itself due to the low serum level
It can be used in high dose as an adjunct though

We need to stop getting to this point …

If you think we can manage with Tigecycline & Colistin. It’s hard.

They are reserve drugs and comes with a lot of drawbacks.

Tigecycline has increased mortality rate when compared to other antibiotics. Colistin is hard on kidneys.

Getting my own talk from yesterday up late.

Also presented at the Big Beasts session on Community-Acquired Pneumonia.

Focused at stewardship folks but something in here for everyone 👇

#SHEASpring2024

#IDTwitter
#MedTwitter

1/

⭐SGLT2i is associated with an ⬆️ risk of genital mycotic infections but not UTI or necrotizing fasciitis of the perineum (Fournier’s gangrene).
⭐In most cases, patients developing mild-moderate or stable severe GU infections can continue SGLT2i (benefits > risks).

Saw this on a referral letter

Is this a new magic potion?

Next up is the Dogmas of stewardship!

Bookmark this thread folks, some great stuff below.

First up is Dr. Jim Lewis.

#SHEASpring2024

1/

Does anyone routinely perform a TOE/TEE before oral switch when treating IE?🤔

Can we afford to do so in real life (as in the POET trial)?

Is it really necessary for patients who are responding to treatment well (to the extent that discharge from hospital can be considered)?

Compared to allergists, evaluation of low-risk penicillin allergy by non-allergists can be comparably effective, safe, and impactful on quality-of-life.

Proud to be part of this

doi.org/10.1016/j.jaip…

Catheter removal based on a defined schedule potentially ⬇️phlebitis/thrombophlebitis according to this systematic review and meta-analysis just published in Clinical Infectious Diseases

No difference on CRBSI or local infections though

doi.org/10.1093/cid/ci…