Dr. Outeiro and colleagues present an informed call-to-action about how to better prioritize the value of basic science research in the Movement Disorders field. loom.ly/cpu8rWc

Prof. Henry Houlden and Dr. Zhongbo Chen share the exciting development of adaptive long-read sequencing and how it helped identify GGC repeat expansions SCA4 using family pedigrees with Swedish ancestry. Movement Disorders Journal loom.ly/FAs4HJo

Fecal short chain fatty acid levels (propionic, acetic, and butyric acid) were lower in iRBD, MSA, and PD participants compared to normal controls. There may be a common gut bacteria signature for people with early manifest synucleinopathies. loom.ly/I2AD33s

Tectal plate length on MRI was shortest in PSP-RS, followed by PSP-P, PD, and Healthy controls. These intergroup differences were statistically significant. Tectal measurements on MRI may have value as a diagnostic marker in undifferentiated parkinsonism. loom.ly/9AWULC4

People with PD describe the physical location of symptoms related to emotions in different spots than expected. PwP described decreased parasternal sensation related to anger with shift toward the abdomen that could reflect cardiac autonomic denervation. loom.ly/igdor8w

An autopsy-based study finds no compelling evidence to suggest synucleinopathies can be transmitted from one conjugal partner to another. loom.ly/QTwPpyI

A group of content experts present Pediatric dystonia clinical recommendations including easy to interpret chart and flow diagrams to guide acute management. loom.ly/IEkBK5Q

In a cohort of PSG-confirmed iRBD participants compared to healthy controls, peripheral blood markers revealed pro-inflammatory lymphocyte markers including changes in CD4+, INF-γ+, and  CD8+ T cell though no differences in T regulatory cell markers. loom.ly/ot50uRE

Cognitive impairment may be relatively common in CANVAS, with visuospatial cognitive impairment showing some correlation with clinical features of cerebellar involvement. loom.ly/dRDRdGY

An auditory cueing device reduced freezing of gait (FoG) in PD when worn but doesn’t appear to alter overall FoG severity in 4-week a pre and post-test design when assessed without wearing the device. loom.ly/B6Ai5tw

Compared to a reference standard of working diagnosis 2 years later the addition of baseline brain MRI to baseline clinical diagnostic criteria for patients presenting with iPD vs PSP vs MSA enhanced overall baseline diagnostic accuracy from 66.2% to 76.1% loom.ly/jDhKtpQ

A placebo-controlled dose-finding trial (n=59) of Lu AF82422, a monoclonal antibody that binds to human α-syn, with preferential binding to aggregated α-syn, showed a reasonable AE profile and dose dependent reduction of plasma and CSF α-syn. loom.ly/HjnHpnw

A Nigerian PD genetic case-control study revealed a novel noncoding variant in GBA1 associated with PD symptoms of REM Sleep Behavior Disorder. loom.ly/SS9XcjE

Congenital mirror movements represent a rate neurodevelopmental condition of unclear underlying etiopathogenesis. A genetic study of 80 affected patients revealed a causative gene in only 1/3 of their total affected cohort. loom.ly/rD7_DYE