A win for Tirzepatide in HFpEF #heartfailure investor.lilly.com/news-releases/…

Big clinical study on clonal hematopoiesis and CVD out: The adjusted hazard ratio (aHR) for CV events for CHIP+ patients was 1.07 (95% CI: 0.99–1.16, P = 0.08) rdcu.be/dQiIw

stroke begets stroke via sensing of neutrophil-derived DNA, shown in new nature paper: rdcu.be/dQmQi

🧵 Excited to share my first preprint from my PhD Kipnis Lab and The Colonna Lab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia." 🧠🦴 biorxiv.org/content/10.110…

Macrophage-mediated myelin recycling fuels brain cancer malignancy Cell cell.com/cell/fulltext/…

Sharing the translational followup to Maarten's AF paper last year. We introduce a drug candidate for atrial fibrillation ❤️❤️‍🔥⚡️ Awesome team effort! Therapeutic Spp1 silencing in TREM2+ cardiac macrophages suppresses atrial fibrillation biorxiv.org/content/10.110…

BCG vaccination alters gene expression and chromatin accessibility in hematopoietic stem and progenitor cells, predicting cytokine secretion in peripheral blood mononuclear cells Immunity Luis B Barreiro Sarah Sun cell.com/immunity/fullt…

Interesting work on T cells in atrial fibrillation. Look like they are hiding in the epicardial fat and fuel the fire from there: 🔥❤️‍🔥💔 rdcu.be/dR2jU

The heart is put at risk of rupture by cells bordering damaged tissue nature.com/articles/d4158…

New paper out in nature examines the beginnings of inflammation after MI. It all starts in cardiomyocytes with sensing DNA leaks out of the nucleus (a defense mechanism against virus infection gone wrong): rdcu.be/dSnqu congrats Kevin King and team!

Engineered human heart tissue reveals pathogenicity of autoantibodies in systemic lupus erythematosus Gordana Vunjak-Novakovic Nature Cardiovascular Research Sharon Fleischer 🎗️ Trevor R. Nash nature.org/articles/s4416… nature.com/articles/s4416…

Excited to share a new work from Kipnis Lab by amazing Wenqing Gao (twitter-less) on developing engineered T cell therapy for CNS injury || nature.com/articles/s4158…

Nature research paper: Alternating high-fat diet enhances atherosclerosis by neutrophil reprogramming go.nature.com/47h9m1O

Fascinating paper shows reaction of skull marrow to adjacent brain tumors in humans. T cells using skull channels? Skull reaction on PET associated with better outcome. rdcu.be/dS3z6 PS: happy to see stellar imaging done in Würzburg :)

Now published in the Sept. 5 issue of Cell: A holistic view of the vascular endothelium as a systemically disseminated organ. Go to cell.com/cell/fulltext/… if you want to learn more about the beauty and importance of endothelial cells in health and disease.