Nature Cardiovascular Research
@NatureCVR
Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology.
ID:1291453724704083968
http://nature.com/natcardiovascres 06-08-2020 19:19:04
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Research|Tuz et al report that #stroke and #MyocardialInfarction induce the release of neutrophil extracellular traps (NETs), loss of B cells and reduced IgA secretion, and that inhibition of NETs prevents loss of IgA in patients and mice. Institute for Experimental Immunology & Imaging
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Research Highlight | Grune et al. in Circulation show that immune activation in acute respiratory distress syndrome (ARDS) induces shifts in #cardiacmacrophages like those observed in individuals with #COVID19 . nature.com/articles/s4416…
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Research| Hu et al. describe how histone H1.0 regulates cellular responses to mechanical stimulation, inducing #myofibroblast activation and coupling force generation to nuclear organization and #genetranscription .
doi.org/10.1038/s44161…
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❤️Our March issue is out❤️ Discover two antibiotics that promote #CardiacRegeneration , find out how the response of liver macrophages to hyperlipidemia drives #atherosclerosis , learn about BRD4 as a regulator of #cardiomyocytes differentiation, and more!
nature.com/natcardiovascr…
Research| Antila et al. show that brain amyloid- β load is not significantly affected by sustained #meningeallymphatics vessel atrophy or hyperplasia induced by lymphangiogenic growth factor manipulation in two mouse models of #Alzheimer .
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Research| Ahmed, Nguyen, et al. identify paromomycin and neomycin as candidates and validate that the combination of these two #antibiotics promotes cardiomyocyte proliferation and improves cardiac function post- #myocardialinfarction . Hesham Sadek
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Research| Brash et al. created the #BulkECexplorer , an online tool to predict active and leaky gene expression in five vascular endothelial cell subtypes commonly used for functional studies. doi.org/10.1038/s44161… @ruhrberglab, UCL Institute of Ophthalmology
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Research| Di Nunzio, Hellberg, Zhang, Ahmed, et al. identify liver macrophages as key cells that organize the systemic responses to #lipoproteins during the initial phases of #atherosclerosis pathogenesis doi.org/10.1038/s44161…
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Horitani and Chavkin et al. report that loss of the Y chromosome in macrophages correlates with fibroblast activation in the myocardium and deficiency in the #epigenetic regulator Uty increases fibrosis and #CardiacDysfunction .
doi.org/10.1038/s44161…
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Research Highlight on the study by Pane et al. published in Circulation Research, where the authors reveal the role of calcineurin as an #epigenetic regulator of #CardiacHypertrophy
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Research | Vargas Aguilar, Cui, et al. report that the #PD1 / #PDL1 checkpoint inhibitor pathway is highly active in the immune cells of newborn mice, and disruption of this pathway impaired #heartregeneration . Stefi Vargas, Eric N. Olson, @UTSWNews
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Research| Jiang and Gao et al. identified that accelerated biological aging measured by clinical traits hints innovative clues for subclinical prevention of cardiometabolic multimorbidity and mortality. Peking University, Harvard T.H. Chan School of Public Health
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Research| With a genome-wide #CRISPR screen in #iPSC , the authors identify the acetyl-lysine reader BRD4 as a regulator of cardiomyocyte differentiation that they subsequently validate in vivo PennCVI Gladstone Institutes UPenn CDB Penn Epigenetics UCSF Cardiology
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