Terrific work by Daniel C. Jones in Evan Newell lab- Proseg is our go-to cell segmentation for all spatial transcriptomics data!

FHIL says check out Proseg cell segmentation by Daniel C. Jones for spatial transcriptomic projects. We use it for our Xenium & CosMx data and it rocks!🎇 biorxiv.org/content/10.110…

Cell Simulation as Cell Segmentation | bioRxiv biorxiv.org/content/10.110…

RECOMMENDED! Our initial tests were like…wait what? 🤯 I’m sure ⁦Fred Hutch Innovation Lab⁩ ⁦Evan Newell⁩ would love some feedback. Cell Simulation as Cell Segmentation | bioRxiv biorxiv.org/content/10.110…

Luciano Martelotto 🛠🧬💻🇦🇺 Fool Fred Hutch Innovation Lab Evan Newell Quick analyses in our lab also show it performs really well. We'll show some plots soon.

#FixNCut, a method for early sample preservation to overcome current limitations in Single-cell omics | ⁦CNAG⁩ ⁦Adelaide Centre for Epigenetics⁩ ⁦Uni of Adelaide⁩ ⁦St. Jude Research⁩ ⁦Omniscope⁩ ⁦South Australian immunoGENomics Cancer Institute⁩ ⁦Peter Mac Cancer Centre⁩ cnag.eu/news/fixncut-n…

Today, I am delighted to share @SheenamVerma30’s work, and the ^ first paper ^ from the Harrison Lab @BRISeattle, published in Immunity -cell.com/immunity/fullt… (1/16)

A Catalog of the Public T-cell Response to Cytomegalovirus biorxiv.org/cgi/content/sh… #biorxiv_immuno

1🔬/ Excited to share our latest preprint led by Shuxiao Chen , Shenggao , Garry P. Nolan , Sizun Jiang , Zongming Ma , and with help from Shalek Lab, Scott and more! biorxiv.org/content/10.110…

Wanna annotate cells in your spatial-omics data but tired of just calling them by their general phenotypes? Hey we got the solution for you! See awesome thread by the hotshot Bokai Zhu, and working with maestros Zongming Ma and Garry P. Nolan

Our former collaborator Evan Newell + others explore ways to determine #cell segmentation accurately in #spatial #transcriptomics in this preprint. bioRxiv Fred Hutchinson Cancer Center pubmed.ncbi.nlm.nih.gov/38712065/

Our first Parse Biosciences Evercode TCR experiment- big appeal is banking fixed cells for TCR. We benchmarked sorted T-cells from 4 healthy donor PBMCs, fixed with v2 reagents, and loaded slightly over the recommended 350k cells to aim for 100k, generating 8 WT & TCR sublibraries. (1/7)

💡Exciting news! Our latest research is now published in Cell: "Therapeutic potential of co-signaling receptor modulation in hepatitis B" 🚀🧵(1/11) 🔬Using mouse models, we traced the development and fate of dysfunctional CD8+ T cells, showing that hepatocellular

Very excited to have Mellon out in Nature Methods today!

extremely excited to share our new story on the impact of JAK inhibition on responses to immune checkpoint blockade in lung cancer patients! 🧬🧑‍🔬 thread on our main findings 🧵 1/n science.org/doi/10.1126/sc…

Excited to share many years of work trying to understand how to promote CD8+ T cell memory cells to improve vaccine protection

We recently benchmarked Fluent BioSciences PIPseq using the v4PLUS T-20 kit. We processed two healthy donor PBMCs in replicate and chose their DSP-Methanol fixation and freezing option since this is often desired for flexible experiment planning. (1/7)

Earlier this week we carried out a preliminary analysis of our first 10x Genomics Xenium prime (5,000 gene) run. We had designed this experiment to get a sense of how the prime chemistry performed compared to the Xenium V1 chemistry.

What did we #learn after #sequencing #5million #Tcells #scRNA and #TCRseq with Lisa Wagar Andreas Tiffeau-Mayer Suhas Sureshchandra and funding agency Wellcome Leap STLChildrensHospital -Tissue determinants of the human T cell receptor repertoire. biorxiv.org/content/10.110…

Preprint alert! A spatial atlas of human gastro-intestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology biorxiv.org/cgi/content/sh…. We examined how immune cells are organized in the gut and what happens to them in GVHD. TL;DR Timing is key!