Our preprint on the ALS/FTD-associated RNA-binding protein FUS’s role in axonal development has now been published in Journal of Neuroscience! We show that expression of FUS variants compromises the integrity / complexity of the distal axonal cytoskeleton. jneurosci.org/content/early/…

Happy to share our mini review in COCEBI written by Mai Dan Nguyen together with Ginny Farias and me. We highlight the exciting emerging role of contacts between the endoplasmic reticulum and membrane-less organelles in protein synthesis and secretion.
authors.elsevier.com/sd/article/S09…

An opinion piece on how phosphorylation of intrinsically disordered domains selectively alters global protein–RNA binding profiles.

sciencedirect.com/science/articl…

Please RT - I have a 12 month research technician post studying resilience to Alzheimer's linked tauopathy.

If you're looking for your next step in your neuro career and have primary/cell culture and molecular biology skills this might be for you! 🧬🧠

qmul.ac.uk/jobs/vacancies…

Excitatory and inhibitory synapses form a tight subcellular balance along dendrites that decorrelates over development biorxiv.org/cgi/content/sh… #biorxiv_neursci

Still looking for a talented and enthusiastic bioinformatician to work with us on a super exciting project on DNA damage and RNA metabolism in motor neuron disease. PataniLab All details here: ucl.ac.uk/work-at-ucl/se… closing on 9th may! UCL Queen Square Institute of Neurology The Crick

Our paper just came out in nature. Congrats to everyone involved, and thanks to our amazing collaborators/former mentors Tony Zador Jesse Gillis Stephan Fischer, and Patrick Kanold. nature.com/articles/s4158…

In a pair of studies published in Cell today, we used interspecies blastocyst complementation to study brain function and evolution. cell.com/cell/fulltext/….
cell.com/cell/fulltext/….

Our lab is #hiring a Postdoc! Wanna do cutting-edge neurosci? Looking for the most awesome, down-to-earth & supportive supervisor? Dreamed of being surrounded by >150 neuro labs McGill University ? Fed up with living in unaffordable cities? This is for you!

Feel free to DM and please RT!

In the second new paper from the lab, we use socRNAs to compare either single or multiple ribosomes on an mRNA and find that ribosomes help each other out during translation to overcome obstacles. Amazing work jointly led by Max Madern and Sora Yang

biorxiv.org/content/10.110…

Two new lab papers: In the first paper we develop Stopless-ORF circRNAs (socRNAs), a technique to measure translation by individual ribosomes with incredible precision. Amazing work jointly led by Max Madern and Sora Yang.

biorxiv.org/content/10.110…

📢 It's time for my lab to continue growing!
We are looking for exceptional postdoctoral candidates to direct projects involving epigenetic mechanisms associated with neurodevelopment and neuropsychiatric disorders.
More info👇👇
tinyurl.com/NeuroATBLab

Surprising discoveries on memory formation, thanks to Ezgi Hacisuleyman Rockefeller University & @HHMINews!
Timely findings eclipse prior data re events within 10min of glutamate receptor activation. Thread = effort x years PDF: rdcu.be/dD8PN nature.com/articles/s4159… 1/8

Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in Genomics England ???

I didn’t initially either, but here is the story of RNU4-2 🧵1/9

Thrilled to share our latest discovery on a spliceosomal snRNA gene causing neurodevelopmental disorders: medrxiv.org/content/10.110… Thank you to everyone who contributed; it’s been a phenomenal effort to collaborate with clinicians and researchers for what would help many families!

Job Alert! Postdoc position is available in the Weatheritt lab in Sydney. An initial 2-year position working on RNA processing in early development. Work is in collaboration with Vi Wickramasinghe's lab at Peter Mac. Email me at [email protected] if interested.

Just online - synaptic phenotypes in #autism associated Chd8 haploinsuffiency strongest in males. Well done Mizuki Tojo & Rob Ellingford for their work, continued great collaboration with Albert Basson 🏳️‍🌈 . CDN | King's College CNDD| King's College
pubs.acs.org/doi/10.1021/ac…

What a PERFFect day to share our new preprint!

With Tsion Abay #BobStickels Meril Takizawa Ronan Chaligne (He/Him) and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

Twittersphere. We are looking for potential beta testers for our 5 channel LED photistimulator. DM if interested.

Do you love #RNA and #neuroscience ? Are you looking for a #postdocposition on #ALS and gene therapy? Join Ruepp Lab UK Dementia Research Institute Institute of Psychiatry, Psychology & Neuroscience and FrattaLab UCL Queen Square Institute of Neurology for a collaborative pre-clinical project on a novel gene therapy approach for ALS. More info here: tinyurl.com/2cpcbsp3