FDA approves nogapendekin alfa inbakicept-pmln for BCG-unresponsive non-muscle invasive bladder cancer | FDA fda.gov/drugs/resource…

FDA approves alectinib as adjuvant treatment for ALK-positive non-small cell lung cancer | FDA fda.gov/drugs/resource…

New Paper Alert! Adjuvant Therapy for Urothelial Cancer in Advances in Oncology

Authors: Charbel Hobeika, MD, Fuat Bicer MD, PhD, Khaled Abouelezz, Shilpa Gupta

oncodaily.com/46149.html

#oncodaily #oncology #cancer #research #BladderCancer #UrothelialCarcinoma #Immunotherapy #ClinicalTrials

New data from EV302 Enfortumab Vedotin & pembrolizumab for upper tract disease (~25% of pts). UTUC has distinct biological features including more FGFR alterations. PFS & OS HR of 0.50 & 0.53 respectively in the subset is in line with the whole population (0.45 and 0.47) #EAU24

Awesome paper Shilpa Gupta Fuat Bicer MD, PhD et al.! OncoAlert UroToday.com Uromigos

Happy to share our review on adj Tx MIUC (pre-EAU) lot of progress w/ IMvigor010, AMBASSADOR, CM274, PROOF302, POUT trials.
Charbel Hobeika, MD Fuat Bicer MD, PhD Cleveland Clinic MD

Adjuvant Therapy for Muscle-Invasive Urothelial Cancer: Current Eviden... sciencedirect.com/science/articl…

📝New publication from Elshad Hasanov, MD, PhD & colleagues:
Advances in non-clear cell renal cell carcinoma management: From heterogeneous biology to treatment options
doi.org/10.1002/ijc.34…

Our Dr. Musa Yilmaz discusses the most recent update of a study of quizartinib, venetoclax, and decitabine in FLT3-internal tandem duplication mutated acute myeloid leukemia. Watch here: brnw.ch/21wHOFs Targeted Oncology Musa Yilmaz, MD #EndCancer

The Spring 2024 FDA-ASCO Fellows Day Workshop was a great success! We always enjoy meeting talented people at the start of their careers who represent the future of oncology!

#OCEProjectSocrates #MedEd
Tatiana Prowell, MD Jennifer Gao @suparnawedam Timil Patel, MD Rick Pazdur

FDA Approves Nivolumab in Combination With Cisplatin and Gemcitabine for Unresectable or Metastatic Urothelial Carcinoma - The ASCO Post ascopost.com/news/march-202…

An outstanding talk by very humble physician scientist Dr. James Brugarolas from @UTSWNews Thank you for HIF2@ inhibitors talk UC College of Medicine

Enfortumab + Pembro outperforms platinum chemotherapy in advanced UC with a doubling of PFS and a halving of the risk of death @nejm. G3/4 AEs of 56% for EVP vs 70% for chemo & CR=29%. Editorial by @gniegisch ‘EVP is the new standard against which future trials must be compared’

Thrilled to welcome Matt Galsky to our esteemed faculty for #WorldGU24 ! Get ready for a #CME meeting packed with up-to-date #GU insights and a stellar faculty. hubs.la/Q02mYDNT0 #bladdercancer #kidneycancer #prostatecancer

✅📖
Best of the year: Advanced breast cancer in 2023
ESMO - Eur. Oncology

➡️HR positive
-PALOMA-2
-MONALEESA-2
-MONALEESA-7
-MONARCH-3
-MAINTAIN
-PACE
-PALMIRA
-BOLERO-2
-SOLAR-1
-CAPItello-291
-TROPION-Breast01
-TROPiCS-02
-DESTINY Breast-04
-PARSIFAL-LONG
-EMERALD
-INAVO120

➡️TNBC…

🚨Targeting p53 in cancer
@NatureRevCancer

⁉️Is it promising?

✅A very comprehensive review
➡️Mechanisms of drugs
➡️Ongoing clinical trials
➡️Protacs
➡️p53 and immune therapy
➡️p53 gene therapy

➡️The dependence of p53 in a specific cancer type?
➡️Need for biomarkers to…

💊Lirafugratinib
Selective FGFR-2 inhibitor
PNASNews

✅do not induce clinically significant hyperphosphatemia or diarrhea
✅73% objective response rate in FGFR-inhibitor naive, FGFR2 fusion-positive intrahepatic cholangiocarcinoma

👉pnas.org/doi/10.1073/pn…

RelayForLife…

Pleased to share PAGA guideline for #gastriccancer . Really appreciate Asian & European experts Lizzy Smyth Tania Fleitas Kanonnikoff George Pentheroudakis Andres Cervantes who joined the discussion. Thank you ESMO - Eur. Oncology and 日本臨床腫瘍学会（JSMO） for excellent support. esmoopen.com/article/S2059-…

Updated table of IO combos (ITT population) in front line mRCC after #ASCOGU24 . Has anything changed for you based on these data?

👏Congrats to Katharine Collier, MD , who received a 5-year, $1.32 million NCI Mentored Clinical Scientist Research Career Development Award to further her bladder cancer studies

Presentation by Elshad Hasanov, MD, PhD The James at ASCO #GU24 bit.ly/48RhBBl