HFrEF ↘️↘️↘️median survival 7-18 years

GDMT ↗️↗️↗️ median survival:

✅ ARNI 2-3 yrs (1-2 yrs vs ACEI or ARB)
✅ BB 3-4 yrs
✅ MRA 2-3 yrs
✅ SGLTi 1-2 yrs

Clinical benefits non-overlapping, incremental, additive

Quadruple >>>triple>>>double

Fast >>>>slow

Now>>>later