A novel protein complex, ChAHP2, is involved in silencing of ERVs and LINE1 elements, complementing the SINE-targeting ChAHP complex, to bring about efficient retrotransposon repression. Marc Bühler Josip Ahel Learn more here: ➡️ tinyurl.com/gd351769

PSAT1 functions as a regulatory link between cellular metabolism, stem cell homeostasis and muscle regeneration. Access this paper and more trending articles from @genesdev at bit.ly/GDArticles #stemcells #ketoglutarate

Daly et al. report a NFκB-p50- and IκBζ-dependent co-regulatory axis that controls differential, inflammatory gene expression in macrophages. Learn more here: ➡️tinyurl.com/gd351630 Also read tinyurl.com/gd351892 for structural insight into IκBζ-p50-RelA interactions

Zhu et al. provide structural insight into how IκBζ, NFκB-p50 and RelA interact to regulate target gene expression. Learn more here: ➡️ tinyurl.com/gd351892 Also see tinyurl.com/gd351630 for how IκBζ and NFκB-p50 co-regulate inflammatory gene expression in macrophages.

Our new paper is now out at Genes & Development ! Big thanks to Neuza R Matias Fabián Morales-Polanco Margaret fuller and all the authors! Without your support and help this paper would not be here today! <3 If you are interested in #germcells and #mRNA processing check it out! genesdev.cshlp.org/cgi/content/lo…

In this study, Guan et al. discover TERT-expressing progenitors in the salivary gland with resistance to radiation-induced damage, suggesting implications for tissue regeneration after radiotherapy in cancers. Learn more here: ➡️tinyurl.com/gd351577

This comprehensive Review Article unravels how DNA and chromatin modifiers (writers, erasers, readers, and remodelers) work, contribute to human disease, and can be therapeutically targeted. #OpenAccess Whetstine Lab Madison A Honer Learn more here: ➡️ tinyurl.com/gd351444

G&D is at Mechanisms & Models of Cancer 2024 #cshlcancer24 CSHL Meetings Come meet the Editors at the Wine & Cheese and get a free G&D T-shirt!

And we made it to the cover! 🎉🎉🎉

We were certainly surprised to find that in human #placental cells the TF #TFEB does NOT control #lysosome gene expr. but instead regulates the expr. of Syncytins to control cell-cell fusion! Excited to see my work now (officially) published Genes & Development 👉m.genesdev.cshlp.org/content/early/…

📽️ G&D Tapes 📽️ G&D author Josip Ahel tells us about a novel protein complex ChAHP2, which along with the ChAHP complex, plays a key role in retrotransposon silencing. Marc Bühler Read the full story #OpenAccess here: ➡️ tinyurl.com/gd351769

In this study, Gloria Jansen et al. use a Drosophila dysgenesis model to show that DNA damage tolerance is a critical protective mechanism for maintaining genomic integrity and survival in germ cells. Felipe Karam Teixeira Learn more here: ➡️ tinyurl.com/gd351701

In this review, McJunkin and Gottesman discuss the mechanisms of RNA degradation and turnover that control the stability and function of small regulatory RNAs, and orchestrate the post-transcriptional regulation of gene expression. Learn more here: ➡️ tinyurl.com/gd351934

In this study, Rongwei Zhao et al. report that SUMOylation, along with DNA repair factors and BLM helicase, promotes telomeric DNA synthesis and alternative lengthening of telomeres. Huaiying Zhang Learn more here: ➡️ tinyurl.com/gd351667

In this study, Lorenzo Gallicchio et al. describe how cleavage factor II (CFII) components serve as a mechanistic switch that controls alternative mRNA cleavage and polyadenylation during spermatogenic differentiation. Learn more here: ➡️ tinyurl.com/gd351649

🎥 G&D Tapes 🎥 G&D author, Lorenzo Gallicchio, tells us about a developmentally-regulated, mechanistic switch that controls alternative mRNA cleavage and polyadenylation during spermatogenic stem cell differentiation. Learn more here: ➡️ tinyurl.com/gd351649

In this Review, Lavorando et al. discuss the roles of sex chromosome-encoded, paired protein homologs in the sexually dimorphic regulation of gene expression and sex biases in disease. Liu Lab (Dr. Kathy F. Liu) Learn more here: ➡️ tinyurl.com/gd351890

In this study, Wen et al. describe a mechanistic link between PRC1 epigenetic regulation and protein degradation, highlighting a tumor-suppressive role for the HYD–LIN complex in regulating the oncoprotein BOWL. Learn more here: ➡️ tinyurl.com/gd351856