💥4 of the trials presented at the Critical Care Reviews were simultaneously published on the NEJM

Which one was your favourite?👇
🫀🫁🩸💊

And don’t miss the fantastic thread by Marilena Marmiere, MD !✅

#CCR24
San Raffaele Anesthesia and Intensive Care
Giovanni Landoni, MD
Martina Baiardo Redaelli
Pragmatic Critical Care Research Group
HEMOTION

We are very honored to have our work, led by Mauricio Machado , cited in the PROTECTION trial published in NEJM. Thank you for the recognition Prof Giovanni Landoni, MD .

Marcelo Nakazone

Further insights from #PROTECTIONtrial

🩸Did AA impact on #hemodynamic ?

📌We found absolutely no differences in vasoactive and inotropic drugs usage, as well as in postoperative mean BP!

👇some of our best findings in the thread below

#CCR24
Giovanni Landoni, MD Martina Baiardo Redaelli

🦋doctor doubt🦋 here it is
follow Marilena Marmiere, MD for a great summary of #ccr24 top presentations/articles

Absolutely thrilled to see a paper led by a great friend Mauricio Machado, and to which I contributed as an author, being cited in the PROTECTION trial published in NEJM! This is more than recognition - it is a tremendous honor! Our deepest gratitude to Prof Giovanni Landoni, MD and his team

3/
#PROTECTION
🧍‍♂️3511 elective #cardiac surgery patients w/ #CPB
🎲Continuous amino acid infusion vs placebo

📌AA are #safe and effective for the #prevention of #AKI (26.9% vs 31.7%) and need for #RRT (1.4% vs 1.9%)

nejm.org/doi/full/10.10…

2/
What are we talking about?

🥩 #PROTECTION - amino acids for #AKI in #cardiac surgery
🤿 #PREOXI - #NIV vs oxygen mask prior to #intubation of critically ill
🩸 #HEMOTION - liberal vs restrictive #transfusion in #TBI
💊 #REVISE - PPI for UGIB in #critically ill undergoing IMV

1/🧵
🤯The medical community worldwide went crazy after the publication of the 4 NEJM RCTs presented Critical Care Reviews in these days!

🧐Did you miss them? Read all the main findings in this thread!

Danny McAuley is editorialising #NAVIGATEtrial :

-Unfunded study
-30% of pts were on RA.
-Only 1000 patients screened in 11 years. -Could there have been a longer intervention period?
-What was usual care?
-Temporal changes in care post COVID? Awake proning? HFNO?

#CCR24

Bryan Reidy Alicia Waite Danny McAuley I think there could get a role for ICU poor countries …Q for the panel is there a role for this in high income countries, would more ICU beds be better? #CCR24 Christopher Nutt

Wow! 😮

This could be huge in #pedsicu David Grant and future of #AKI in CPB. Fascinating work 👏🏽

#CCR24 Critical Care Reviews #NAVIGATEtrial
What should SOC be for ARF outside the ICU?
Would study replicated nowadays include more HFNC in UC group?

ERC guidelines on use of HFNC:
Simon Oczkowski
pubmed.ncbi.nlm.nih.gov/34649974/

Giacomo Monti seems to be suggesting a generational gap in terms of equipoise about the use of NIV while setting up the background for the #NAVIGATEtrial #CCR24 (with Giovanni Landoni, MD)

2 related questions for Giovanni Landoni, MD & Giacomo Monti re their #CCR24 #NAVIGATEtrial :

1) What was the role of RTs in managing the BiPap? Were they followed closely? Feature of the intervention or confounder? Certainly having an RT follow closely could change outcome. 1/2

Andrew Helt Agreed 👍 could have big implications in LECs

Impressive reduction in progression to severe respiratory failure in patients treated with protocolised early NIV in the #NAVIGATEtrial . #CCR24

Register for CCR Down Under ASAP… before #ccr24 withdrawal symptoms take hold! 😄 We’d love to see you in Melbourne for more ⁦⁦Critical Care Reviews⁩ magic, December 10th & 11th, 2024 criticalcarereviews.com/meetings/ccr-d…

Please vote 🗳️ 👉👉👉

My first manuscript as co-first author! Thanks to all the senior authors
Alberto Zangrillo Giacomo Monti LauraPasin Martina Baiardo Redaelli Girardis Massimo Giovanni Landoni, MD
signavitae.com/articles/10.22…