Optimizing Clinical Implementation of Hypofractionation: Comprehensive Evidence Synthesis and Practical Guidelines for Low- and Middle-Income Settings mdpi.com/2654488 #mdpicancers via Cancers MDPI Dr. Fabio Moraes Gustavo @andregouv Andre G, MD, Rad Onc 🇧🇷 🇮🇹 🇨🇦

🎙 dose-escalation RT efforts for 👥 with #Colorectal liver metastases❗️OncoAlert Memorial Sloan Kettering Radiation Oncology
📌RETRO STUDY
Patients:90 w/ 122 treated lesions (2006-2019)
Treatment:Various RT schemes, median dose 97.9 Gy
📊RESULTS
➖Median FU:26.4 m
➖Local control (FFLP) at 2 y:42%
➖OS at 2…

🎙 HARD RT shows promising locoregional control with acceptable tox for unresected STS❗️❗️OncoAlert a
📌Retro study- HARD RT applied to unresected STS (2019-2022), 27 👥
Dose Variation:HR: 3.0 Gy, IR: 2.5 Gy, LR: 2.0-2.3 Gy per fx
📊RESULTs
-FU Median 33.4 m
-100% LC at 3 y…

🎙SBRT produces excellent local control and ⬇️⬇️ complications for non-spine bone metastases(NSBM)❗️OncoAlert Dr. Fabio Moraes Andre G, MD, Rad Onc 🇧🇷 🇮🇹 🇨🇦 IJROBP - The Red Journal
🥇🎯efficacy and safety of SBRT for NSBM
📌SR/MA of 7 studies (807 👥/1048 llesions)
📊RESULTs
- 1-y LF and fracture rates…

🎙️ CCRT significantly ⬆️ OS for the older 👥 w/ stage II #NPC ✖️
IMRT alone‼️OncoAlert Radiotherapy & Oncology
📌Propensity score matching 53 👥 each in CCRT and IMRT
👥 (age ≥ 60 years) w/ stage II NPC
🥇🎯 OS, PFS & DMFS
📊Results
- Median fU: 82.0 m
- CCRT ⬆️ 5-y CSS (98.1%…

🎙️ Primary 🔪 was an 👎 strategy, compared to preop CRT ➡️🔪, and cannot be recommended for #rectalcancer 👥 in the clinical practice‼️OncoAlert IJROBP - The Red Journal
📌RCT on LARC 👥 (6–12 cm) w/ (-) MRI-predicted MRF. Randomized into intervention (primary 🔪 w/ selective CRT) or control…

🎙️SBRT is a viable alternative for medically inoperable or high-risk #renalcancer ‼️OncoAlert The Lancet Oncology
📌SR, based on 36 studies (822 👥)
📊Results
- Median LC rate: 94.1%
- 5-y PFS: 80.5%
5-y OS: 77.2%
- Practice guidelines recommend 25–26 Gy in 1 fr or 42–48 Gy in 3…

🎙️ SF-SBRT for peripheral early stage #NSCLC is an effective treatment approach‼️‼️OncoAlert
📌 Retro study of biopsy-proven cT1-2N0M0 NSCLC
- 1x fx (SF-SBRT) w/ 27 Gy or 30 Gy
📊Results:
- 263 👥, median age 76, median FU27.2 m
- Tumor size median 1.9 cm, 85% T1
- 2- and…

Dear Colleagues,
Out Tomorrow, The OncoAlert 🚨Newsletter

REGISTER at OncoAlert360.com OR oncoalert.m-pages.com/nhMpwe/oncoale…

Discussing🎄
✅SPLASH in #ProstateCancer 💦
✅Top Advances in #OvarianCancer 🦀
✅Risk for early #PancreaticCancer
✅Precision Medicine in Urothelial…

Actions are needed to promote Radiation therapy capacity expansion in Brazil - Dr. Fabio Moraes
Timothy Hanna

#Brazil #Brazil ianRadiotherapy #RadiationOncology #Oncology #Cancer #OncoDaily #RadiationTherapy #Cancer Care

oncodaily.com/26458.html

🎙️ Oligoprogression in 👥 w/ metastatic #NSCLC could be effectively treated
w/ SBRT ➕SOC‼️@oncoalert The Lancet
📌Ph 2, RCT
- SBRT in oligoprogressive metastatic breast cancer or NSCLC
- Oligoprogression ≤5 lesions on PET-CT or CT
- 1:1 Random to SOC vs. SBRT + SOC
📊RESULTs…

The Brazilian RT expansion plan showed substantial delays in most projects.
Significant delays were observed in the basic and construction projects phases.
Actions are needed to promote RT capacity expansion in Brazil.

Queen’s Global Oncology Program Gustavo Andre G, MD, Rad Onc 🇧🇷 🇮🇹 🇨🇦 Dr. Gustavo Nader Marta, MD, PhD

Truly OUTSTANDING work by MD Anderson Cancer Center Jillian Gunther on her Ph2 trial of response adapted ultra low dose (4Gy) RT for gastric MALT. 24 pts,4 required the additional 20 Gy.All pts had a CR to the response adapted program, 3yr LC 96% & 3yr freedom from distant relapse 96% #ASH2023

🎙️ PORT was 🔁 w/ a ⬆️ OS benefit in 👥 w/ advanced stage #Thymiccarcinoma after an R0 or R1/2 🎙️‼️OncoAlert
📌Retro study, 462 TC 👥
🥇🎯: OS
🥈🎯: Time to Relapse (TTR)
📊RESULTs
- PORT 🔁 ⬆️ OS benefit (5-y OS 68 vs 53%; p=0.002)
- R0 resection w/ PORT ⬆️ OS in…

🎙️Data from a meta-analysis suggest advantage of TMT when
compared to other reconstructive 🔪scenarios for #bladdercancer ‼️OncoAlert
📌Meta-analysis on bladder cancer treatments (1999–2021)
🥇🎯: QoL: ICUD x orthotopic neobladder (ONB)x TMT
📊RESULTs
- ONB shows significant…

🎙️ mpMRI predicts PSA outcome in #prostatecancer 👥 treated w/SBRT‼️OncoAlert
📌Retro study, 👥 undergoing SBRT
- Pretreatment mpMRI as prognostic features
📊RESULTs
- 123 👥 included
- Pre SBRT MRI 🔁 PSA nadir and time to nadir (p<0.0001)
- 🔁 persisted in 👥 not…

🎙️Avasopasem w/ SBRT showed efficacy in advanced #pancreatic cancer ‼️@oncoalert The Lancet Oncology
📌Ph 1b/2 trial, randomized, double-blind, placebo-controlled
- 👥 (n=42) received avasopasem or placebo before SBRT
🥇🎯: Evaluate avasopase w/SBRT
📊RESULTs
- Avasopasem…

In order to present suggestions to improve the Radiotherapy Expansion Program in the Unified Health System (PER-SUS) we conducted a detailed study available at the link below.
sciencedirect.com/science/articl…
Thanks to all the authors! Dr. Fabio Moraes Gustavo Dr. Gustavo Nader Marta, MD, PhD

Thankful for sharing the exciting news that our collaborative scientific work between Hospital de Amor and HCFMRP USP on hypofractionated radiotherapy with chemotherapy for lung cancer has been awarded as the best at the Brazilian Congress for Medical Residents. An honor to work…

🎙️ Caution🚨 in routinely delaying 🔪 for >6 weeks after nCRT for #esophagealcancer ‼️OncoAlert
📌Ph 3 RCT comparing standard (4-6 W) ✖️prolonged (10-12 W) time to 🔪after nCRT for oesophageal cancer
🥇🎯:Complete histological response
📊RESULTs
-N🚫 sig # in complete…