Preprint alert! The force-sensitive protein, FHL2, promotes atherosclerotic endothelial phenotypes (junction discontinuity, hypercontractility, and high tissue permeability) through actin-microtubule crosstalk!! Check out the whole story on bioRxiv: biorxiv.org/content/10.110…

Jeremy Keys, Jan Lammerding Lammerding Lab and colleagues Cornell BME Weill Institute for Cell & Molecular Biology find that rear cortex contraction aids in nuclear transit during confined migration. Highlight: journals.biologists.com/jcs/article/13… Article: journals.biologists.com/jcs/article/13…

Nice to catch up with my PhD supervisor Lu-Yun Lian after 20 years! Time sure flies.

Very happy to share our new paper in JCellBiol, "TLNRD1 is a CCM complex component and regulates endothelial barrier integrity", great collaboration with Guillaume Jacquemet, and well done Neil Ball and Sujan Ghimire 🇳🇵🇫🇮 for pushing this to completion Inst of Systems, Molecular & Integrative Biology doi.org/10.1083/jcb.20…

Very happy to finally share our JCellBiol work on TLNRD1! It was a very exciting process of discovery when we found it was an important CCM complex component and required for vascular development rupress.org/jcb/article/22…

Ball, Sujan Ghimire 🇳🇵🇫🇮, Ben Goult, Guillaume Jacquemet et al. Turun yliopisto - University of Turku show that the actin-bundling protein TLNRD1 is a key player in maintaining the integrity of endothelial cells. By binding to CCM2, TLNRD1 is an integral component of the CCM complex. hubs.la/Q02GX73n0

🎓 Exciting News from the Mechanobiology Institute! Our PhD programme registration is now open for August 2025 intake! Embark on a journey of cutting-edge research with us. Find more details in the leaflet below or visit mbi.nus.edu.sg/education. 📚🔬 #PhD #Research

Join us in Liverpool to celebrate our 100-year anniversary. Check out the fantastic speaker list for the cell and developmental biology track here: 100yearsconference.biologists.com/programme/cell…

Delighted to share the updated version of our #CellTracksColab paper published in PLOS Biology journals.plos.org/plosbiology/ar… Fantastic work by Estibaliz Gómez de Mariscal, PhD Hanna Grobe, Joanna Pylvänäinen Laura Xénard, Ricardo Henriques and Jean-Yves Tinevez

Excited to announce…..it’s finally arrived (!!) nature.com/articles/s4155… A big thank-you to my team (particularly Robert Ju), co authors & #FutureFellowship funding from Australian Research Council Importantly- a big shoutout to Daryl JV David Nature Cell Biology for their support. 👇tweetorial 👇

"How Colorful Ribbon Diagrams Became the Face of Proteins" A great article about Jane Richardson's ribbon diagrams and the pros/cons of different types of protein visualization quantamagazine.org/how-colorful-r…

Researchers at Åbo Akademi University and @livuni have discovered a crucial protein, TLNRD1, that could help us better understand and treat Cerebral Cavernous Malformations (CCM) disease! abo.fi/en/news/new-st…

New paper. Molecular dynamics simulations can recapitulate what we can measure experimentally, which validates the approach, but they also allow insight into the bit that occurs at a resolution we cannot see, including how vinculin can engage partially unfolded talin helices.

New Paper. What is becoming clear is that because talin is so multifunctional and structurally so plastic even relatively subtle talin mutations (usually classified as non-pathogenic by pathogenicity prediction tools) are sufficient to cause disease. Inst of Systems, Molecular & Integrative Biology

New Paper. Very happy to have been involved with this study by Martin Schwartz's team Yale University published in Science Advances. It provides a direct demonstration that talin 1 stiffness sensing is important for tissue mechanical homeostasis Inst of Systems, Molecular & Integrative Biology science.org/doi/full/10.11…

September issue of JCellBiol also contains our new paper on TLNRD1 (talin rod domain containing 1) protein and its role in the Cerebral Cavernous Malformation complex. rupress.org/jcb/article/22… Guillaume Jacquemet Inst of Systems, Molecular & Integrative Biology School of Biosciences, University of Kent Turun yliopisto - University of Turku