It was great to see all the lively discussions between researchers from all of our institutes at the poster session of the #LED3Symposium. We had a very high quality of posters with an amazing diversity of topics and a lot of interdisciplinary connections.

Great talk by Bert Beerkens at the #LED3Symposium. He talked about his research on the development of labeling reagents for the adenosine A2B receptor using ligand-directed chemistry. Interesting application of N-acyl-N-alkyl sulfonamide (NASA) chemistry.

Great talk by Nataliia Machushynets at the #LED3Symposium. She talked about her research in the group of Gilles van Wezel 💙💛 into new tridecaptin antibiotics with enhanced biological activity. An exciting interdisciplinary project across several Leiden Early Drug Discovery & Development (LED3) groups.

Great science at the Flash Talk session of the #LED3Symposium. Amazing to see all the diverse topics including antibiotics, cyclic peptides, GPCRs, genome mining, hydrogels, covalent inhibitors and many more that are covered in interdisciplinary projects within the Leiden Early Drug Discovery & Development (LED3).

Great talk by Sophie Wintermans at the #LED3Symposium. She talked about her PhD research in the group of Marta Artola into a high throughput screening method for RNA-binding small molecules on the example of the PreQ1 riboswitch. biorxiv.org/content/10.110…

The final keynote lecture of the #LED3Symposium was given by Nathaniel Martin. He talked about his group's amazing research into inhibitors of the cancer driver protein Nicotinamide N-methyltransferase (NNMT). sciencedirect.com/science/articl…

We had an amazing day with a lot of exciting, interdisciplinary science at the #LED3Symposium. Over 120 participants took part in our event and learned a lot about early drug discovery projects across the Leiden Early Drug Discovery & Development (LED3) institutes LeidenScience ENG Leiden Science Universiteit Leiden.

At the #LED3Symposium, we also announced next year's #LED3Lectures with an amazing program including Emily Balskus, Andrew Leach, Tjeerd Barf, Picotti Lab, Andrea Rentmeister, Jeff Kelly, John P. Overington, Kim Lewis, Ed Tate and Jay Keasling.

LED3’s first PhD/Postdoc symposium was a big success!🎉 Researchers from different Leiden Science institutes presented their interdisciplinary research on Early Drug Discovery. Read more about the collaboration: universiteitleiden.nl/en/science/led3 #LED3Symposium

Really happy to share the open access publication of one of my PhD projects in RSC Chemical Biology! We developed an affinity-based probe featuring an infrequently utilised metal chelator to study metalloproteins in live cells. pubs.rsc.org/en/content/art…

Great paper from the groups of Joanna McGouran and Sander van Kasteren with first author Sean M. McKenna in RSC Chemical Biology. Fully-functionalized probes based on the metal chelator 8-mercaptoquinoline for affinity-based protein profiling of metal-binding proteins. doi.org/10.1039/D4CB00…

Can you improve an antibiotic that has been in clinical use for 75 years? The group of Nathaniel Martin of the Leiden Early Drug Discovery & Development (LED3) addressed this question by developing bacitracin analogs with enhanced activity against vancomycin-resistant enterococci (VRE). pnas.org/doi/10.1073/pn…

MC4DD: New EU consortium on drug discovery dedicated to macrocycles. 8 universities and 6 industry partner join forces to advance the science of macrocycles as drugs. More information: MC4DD.com

A focused library of site-specifically acetylated Max transcription factor analogs was chemically synthesized to dissect the role of Lys-acetylation in its DNA binding activity NEW #ASAP by @jbaram90 @afek7afek Read it here: go.acs.org/a9D

Our team Institut Chimie Nice Université Côte d'Azur recently obtained a EU Horizon MSCA grant as part of the doctoral training network TargetRNA uib.no/en/targetrna !! Apply to work on targeting bacterial riboswitches to discover new antibiotics ! #medchem #chembio #RNAtargeting

Amazing news that two projects involving Leiden Early Drug Discovery & Development (LED3) scientists have been awarded funding through NWO Funding Open Competition M2 grants. Congratulations to Sebastian Pomplun and Matthias Barz from the LACDR as well as Sander van Kasteren from the LIC. nwo.nl/en/news/twenty…

Can you simultaneously improve the potency and safety profile of a clinically used antibiotic? The group of Nathaniel Martin of the Leiden Early Drug Discovery & Development (LED3) presents the guanidino lipoglycopeptide antibiotic class with potent antibacterial activity in Science Translational Medicine. science.org/doi/10.1126/sc…

Come join us at EPFL! We are looking to fill a new position for a Tenure Track Professor in Chemical Biology! Find all info how to apply here: epfl.ch/about/working/…

Thrilled to share our latest work on the late-stage, site-specific chemical insertion of aromatic PTMs into proteins, published today in J. Am. Chem. Soc. A big thanks to LashuelNeuroLab for the exciting collaboration. Congratulations to Lin, Shaswati, and the team! pubs.acs.org/doi/10.1021/ja…