FOR THE LOVE OF PURINES: We are truly excited to share our latest work on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors Cell Press. A huge team and collaborative effort! Congratulations, ALL!

How does metabolism influence lineage commitment? How do nutrition & redox impact cell fate? Why do some #IEMs cause developmental defects? Interested? Repost and attend the Keystone Symposia below, May 7-9, 2025. Lydia Finley and @rjdlab organizing. -RJD keystonesymposia.org/conferences/co…

Check out this great study from the Delgoffe Lab and Muir Lab about how phosphoethanolamine controls T cell signaling by diverting diacylglycerol towards PE synthesis. Clearly lots to learn about how intermediates of the Kennedy pathway are regulated in cells!

Excited to share our newest pre-print by Xueqian Zhuang on how aging suppresses tumorigenesis and stemness in the lung by promoting a functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis: biorxiv.org/content/10.110…

Paper out!📢 Anupriya Singhal and #HannahStyers from the lab find acute resistance to targeting KRAS in pancreas cancer is surprisingly driven by a classical epithelial state. Co-targeting classical cells and KRAS augments response - clinically important! aacrjournals.org/cancerdiscover…

Components of normal tissue architecture maintain structure (+ fxn) & serve as barriers to tumor progression…but how? We report a 🧩 in our new preprint. Congrats to 1st author M. Kathrina Oñate & thx to collabs Memorial Sloan Kettering Cancer Center OHSU Knight Cancer Institute Stanford Medicine! 1/ biorxiv.org/content/10.110…

Excited to hear #CSMito2024 co-organizer and speaker Lydia Finley discuss metabolic control of normal and pathological cell states Cell Symposia Oct 27–29, 2024 in Sitges, Spain hubs.li/Q02JCK_-0

Our latest work just came out in its final VOR form eLife - the journal, wherein we describe our efforts to optimize sequencing-based measurements of tRNA aminoacylation using tRNA-seq, via improvements to RNA stability, ligation efficiency, and data processing. elifesciences.org/articles/91554

Very happy to see our first paper out! We characterize transcriptional isoforms of NAD+ kinase (NADK) and their role in oxidative stress and melanoma metastasis. Huge congratulations to Graciela Grace for all the hard work! doi.org/10.1016/j.redo…

Metabolic regulation of the hallmarks of stem cell biology by Jackson (Benjamin Jackson) and Finley (Lydia Finley) hubs.li/Q02JJ03D0 Collection highlight from Cell Stem Cell

The #FrankfurtCancerConference is approaching fast! In Session 5 we’ll be looking at Metabolism at the Tumor-Host Interface with talks by Iannis Aifantis , Hubert Serve, Lydia Finley and Sarah Fendt Lab. Check out the program here: frankfurtcancerconference.org