Very nice work! With no iv lead in, further evidence that clinical criteria, and not some arbitrary, magical duration of iv lead in, is the key to going oral.

Patients diagnosed with a low-risk BSI after their discharge from the ED can be safely treated with a fully-oral ambulatory course of antibiotics #oralisthenewIV

🆓🔓 Our latest paper in #AAC 👉🏻 journals.asm.org/doi/epub/10.11…
#IDtwitter Antibiotic Steward Bassam Ghanem🆔🌟 Brad Spellberg Pranita Tamma

Supe⚡️ Supe⚡️ inte⚡️esting
Fear of Missing Organisms (FOMO): the discordance among broad-spectrum empiric antibiotic therapy, microbiologic results, and definitive antibiotic therapy for diabetic foot infections and lower extremity osteomyelitis #IDXposts
cambridge.org/core/journals/…

🆕️⚡️✨️Review Marc H. Scheetz et Al
Contemporary pharmacologic treatments of MRSA for hospitalized adults:rationale for vancomycin Vs non-vancomycin Rx as first line agents
Linezolid
Daptomycin
Ceftaroline
Ceftobiprole
What do you think, ID folks?
tandfonline.com/doi/full/10.10…

Congratulations to NATASHA HALASA Halasa Lab who continue to lead efforts to understand the optimal approach to protect immunocompromised patients from influenza through vaccination.

The first major studies focuses on pediatric HSCT patients.

academic.oup.com/cid/advance-ar…

Supe⚡️ inte⚡️esting
A prospective single-center study
Rate & predictors of blood culture positivity after antibiotic administration
The overall rate of patients with a positive blood culture after a single dose of antibiotics was 42.0% (55/131 patients).
link.springer.com/article/10.100…

The risk AmpC derepression is not equal among Enterobacterales!
🆕️⚡️🌟An antimicrobial stewardship intervention was associated with ⬆️ ceftriaxone prescribing & similar patient outcomes in patients with severe infections with low & no-risk AmpC E #MedEd
journals.asm.org/doi/10.1128/aa…

🆕️🌟Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study🌟🆕️ Brad Spellberg #IDXposts #IEWiki #MedEd academic.oup.com/eurheartj/arti…

Excited to kick off some fun & learning via ID Jeopardy led by #IDFellowship Program Director, Dr. Michael Angarone!

Publication Alert

This systematic review and individual patient data meta-analysis concluded that TMP-SMX prophylaxis reduces the risk of nocardiosis in solid organ transplant recipients Zach Yetmar Matteo Passerini Clinical Microbiology and Infection
bit.ly/4935X76

#IDTwitter
Can you switch to oral abx for beta-hemolytic strep bacteremia in pts who are severely immunocompromised?
Let’s find out 🧵
Mackenzie Keintz, MD

Excellent⚡️🌟
In vitro susceptibility patterns for slowly growing NTM US 2018 to 2022
32 different species/subspecies
80% MAC
MAC S :
94% to 100% susceptible to clarithro
64% to 91% to amikacin
2% to 31% to linezolid
4% to 41% to moxi
#IDXposts #MedEd academic.oup.com/jac/article/do…

🆕️⚡️In vitro susceptibility patterns for slowly growing non-tuberculous mycobacteria in the USA from 2018 to 2022⚡️🆕️
🌟Antibiogram for slowly growing non-tuberculous mycobacteria with ≥15 isolates in the USA from 2018 to 2022🌟 #IDXposts #MedEd academic.oup.com/jac/article/do…

Gram-negative bacteria are intrinsically resistant to many antibiotics,due in large part to the permeability barrier formed by their cell envelope
🌟Excellent review 🌟
Gram-negative permeability barrier:tipping the balance of the in and the out #IDXposts
journals.asm.org/doi/10.1128/mb…

🆕️⚡️🌟Systematic review and Individual Patient Data Meta-Analysis Clinical Microbiology and Infection
Trimethoprim-Sulfamethoxazole Significantly Reduces the Risk of Nocardiosis in Solid Organ Transplant Recipients #IDXposts
clinicalmicrobiologyandinfection.com/article/S1198-…

🔥 SOAB RCT🔥 Clinical Microbiology and Infection
In patients with Enterobacterales bacteraemia, oral switch, after initial IV antimicrobial therapy(3-5d) ,clinical stability, and source control, is non-inferior to continuing IV therapy
Cc Steven Tong #IDXposts
clinicalmicrobiologyandinfection.com/article/S1198-…

Michael Angarone Alice Han Nico Cortes-Penfield MD FACP 🦴💊 GERMAN ESPARZA🔬🦠🧫 Barbara Trautner Tremendously important and valuable experience Michael!

Also worth noting non-susceptible rates are generally ⬆️ for CIP compared to LEV. doi.org/10.1186/1471-2…