Why are so many inherited traits not explained by genome sequence variation? In my PhD work with Brent Derry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵nature.com/articles/s4155…

Delighted to share our new manuscript on protein-based trait inheritance. This work was the blood, sweat and tears of former PhD student Dr. Matthew Eroglu. A tour de force and a testament to his dedication to detail. Lookout for this talented scientist when he is on the job tour.

Not DNA Not RNA Not even epigenetic marks Inherited amyloid proteins nature.com/articles/s4155…

Inter-generational epigenetic control to help explain the “missing heritability” problem? Wow.

I was waiting for a long time for this exiting paper to be published. Congrats Brent Derry and Matthew Eroglu! nature.com/articles/s4155…

Protein-based inheritance! WOW! nature.com/articles/s4155…

Figure 8. is MIND-BLOWING!! Read it! nature.com/articles/s4155…

Noncanonical inheritance of phenotypic information by protein amyloids nature.com/articles/s4155…

Noncanonical inheritance of phenotypic information by protein amyloids. nature.com/articles/s4155…

Des amyloïdes héritables influencent les traits chez les animaux,agissant comme une mémoire épigénétique Leur perturbation peut altérer les phénotypes,transmis à la progéniture, et le protéasome 26S les régule sur plusieurs générations nature.com/articles/s4155… Bocquet Annelise 🔬🧬📚🚜

Yeah, so I read this paper yesterday when it was first posted. And my eyebrows were raised the entire time. If this holds up, this is gonna change a whole bunch of stuff in our understanding of neurodegeneration.

Brent Derry Matthew Eroglu Awesome work from a fantastic team. Happy to see this out!!!

A study led by Dr. Brent Derry offers new insight into the biological phenomena of missing inheritability – a term describing traits that are passed on through generations but not genetically traceable. 🔬 Read the #SKResearch in Nature Cell Biology ➡️bit.ly/3TdZeB5

😮😮🤯 "...heritable amyloids across generations, which enables proper germ cell sex differentiation. We propose that inheritance of a proteinaceous epigenetic memory coordinates developmental timing and patterning with the environment to confer adaptive fitness."

nature.com/articles/s4155…

Excited to share that I’ve been awarded a fellowship from the American Parkinson Disease Association (APDA)! Huge thanks to APDA for the generous support and to my mentor, Dr. Lorenz Studer, for his guidance! American Parkinson Disease Association Lorenz Memorial Sloan Kettering Cancer Center

Can we all have a moment of sympathy for DNA – it has had a rough week 🧬 First, proteins not predicted by genetic code 😮 biorxiv.org/content/10.110… Then, inheritance without genes through amyloid protein 🤯 nature.com/articles/s4155… Biology is amazing!

Thank you for the interest in our work! Happy to answer any questions if I can…