Max Gutierrez
@maxgabgut
Cell Biologist ๐ฆ๐ท&๐ฌ๐ง @thecrick via @embl @helmholtz_de | #phagosomes #imaging #tuberculosis #macrophages #iPSC and #wine @maxgg.bsky.social
ID:855641563745189888
https://www.crick.ac.uk/research/labs/maximiliano-gutierrez 22-04-2017 04:37:00
7,0K Tweets
4,6K Followers
1,3K Following
Follow People
Luiz Pedro Carvalho
๐ง๐ท & ๐ฌ๐ง Professor @UFScripps @UF & Visiting Group Leader @TheCrick #enzymology #antibiotics #Mycobacteria #tuberculosis #metabolism #chembio #metabolomics
Olivier Neyrolles
Director of https://t.co/KecVeEb5nw Toulouse ๐ซ๐ท๐ช๐บ Passionate about microbes & some other stuff #SciComm | #CNRS | Views my own
The Crick
We are a biomedical discovery institute breaking down barriers between disciplines. A space where some of the world's most talented scientists pursue big ideas.
Pierre SANTUCCI
PI @CNRS @LISM_CNRS_AMU @univamu ๐ซ๐ท๐ช๐บ Tuberculosis, NTM & antibiotics ๐ ๐ฆ ๐ฌ Postdoc Formerly @maxgabgut @TheCrick ๐ฌ๐ง @MolMicroEditors ๐ฐ (He/him)
claudio bussi
Postdoc Fellow @TheCrick @maxgabgut #mitochondria #lysosomes #condensates - Former @EuroRespSoc @Mariecurie_alum Fellow (he/him)
Congratulations to Anne OโGarra on being elected to the National Academy of Sciences for her distinguished and continuing achievements in immunology research๐
crick.ac.uk/news-and-reporโฆ
Interested in quantitative imaging, iPSC models, organelle function, genome editing, or maybe all of the aboveโบ๏ธ? Check out these Project Officer and Research Fellow (postdoc) positions to join my lab in sunny Singapore! bussilab.com
๐๐
ntu.wd3.myworkdayjobs.com/en-US/Careers/โฆ
New drug against #Tuberculosis : Alexandra Maure Ludovic Tailleux &co identify an #oxadiazole -based compound that induces #zinc redistribution in host cells, synergizing with other anti- #TB drugs to control infection in human #macrophages & mice #PLOSBiology plos.io/3w60MVs
Uncover how these two bacteria exchange antimicrobial resistance between themselves and with millions: no, trillions of others across EU-African ecosystems.
Ready to combat them with AI and big data?
Apply for a 4-year Biotechnology and Biological Sciences Research PhD with our ๐ฟ๐ฆ๐จ๐ญ๐ซ๐ท๐ฌ๐ง๐น๐ท๐ณ๐ฌ๐บ๐ฌ๐ฎ๐น๐ง๐ท๐จ๐ณ๐ง๐ฉ๐ฒ๐พ๐จ๐ฑ team ๐
๐New Preprint! Here we highlight the potential of natural product-inspired derivatization approaches for drug discovery using our #Dicty and M. marinum infection system !
Great job from twitterless J. Nitschke and Nabil Hanna in collaboration with Emerson lab Faculty of Science | UNIGE
Check out our latest paper science.org/doi/10.1126/scโฆ. Congratulations to Evangelos Giampazolias who led the work. Thanks to very many who helped. Great collaboration with Tine Jess and Romina Goldszmid labs. Tweetorial will follow soon.
#Lysosomes are crucial cellular degradation centers, but how can one selectively modulate their activity? This study describes novel #optogenetic tools for the light-inducible manipulation of lysosomal physiology in cells & in #Celegans #PLOSBiology plos.io/49WGds5
Check out our latest on measuring antibiotic response in M.tuberculosis using gene expression ๐
A monolithic effort by Husain Poonawala
๐ขNEW #Preprint , Brainchild of Jose Juliรกn with Alessia, Peng & our amazing collaborators. Topics covered #ATG8ylation , #cell_wall_damage , #vacuolar_quality_control , #mechanostasis . biorxiv.org/content/10.110โฆ Intrigued? See the ๐งตfor a summary:
I am excited to share my first project in Wade Harper for feedback. We used spatiotemporal proteomics (1) to describe how cells respond to NLRP3 agonists and (2) to profile the proximal proteome as NLRP3 trafficks to the site of inflammasome nucleation harperlab.pubpub.org/pub/nlrp3/
Our latest preprint (not peer reviewed yet). Influenza's M2 proton channel is cleaved by caspases to remove the LIR motif. We solve co-crystal structure of M2 and LC3 to show it's not overlapping with cleavage site. Great collaboration with Avinash Shenoy. biorxiv.org/content/10.110โฆ
A patient perspective from North London: UK patient with multidrug-resistant tuberculosis or why we need new drugs for #tuberculosis The Lancet Respiratory Medicine
thelancet.com/journals/lanreโฆ
'the reliance on transcriptomics to define cell types comes with intellectual hazards.' Wisdom from West Lab @ Duke ๐
These snapshots miss the dynamics of plasticity (or other cell states). thetransmitter.org/defining-cell-โฆ
Our review on the Endo-Lysosomal Damage Response now out in Annual Reviews Biochem, discussing also the basis of membrane damage/permeabilization. #lysophagy #lysosome #ubiquitin
annualreviews.org/content/journaโฆ
![Antibiotics help to prevent and treat infections. We need a pipeline of new ones to fight infections because over time they become resistant to the drugs we use to treat them. Yet, no new classes of antibiotics have been approved since the 20th century. [1/3]](https://pbs.twimg.com/media/GKolfEuXEAA6pDL.jpg "Wellcome (@wellcometrust) on Twitter photo 2024-04-08 09:58:49 Antibiotics help to prevent and treat infections. We need a pipeline of new ones to fight infections because over time they become resistant to the drugs we use to treat them. Yet, no new classes of antibiotics have been approved since the 20th century. [1/3]")
Preprint: A single-cell transcriptomic atlas of the lungs of patients with pulmonary #Tuberculosis
researchsquare.com/article/rs-275โฆ
This is the 1st single-cell transcriptomic landscape of the human lung after TB infection, showing disease-associated cell type-specific molecular profiles..
I am excited this is now published with eLife - the journal.
LRRK2/actin cytoskeleton/synapses is a favorite recurring theme of mine ๐. A fun collaboration with Elisa Greggio
'LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton' doi.org/10.7554/eLife.โฆ