🗓️Deadline approaching🗓️ 3 weeks left to submit an abstract for a presentation slot at the 2024 Mitochondria and Chloroplasts GRS. Early career researchers in bioenergetic organelles don’t miss this chance to show your cool science!!

Pre-trained using over 33 million single cell RNA-seq profiles, scGPT is a foundation model facilitating a broad spectrum of downstream single-cell analysis tasks by transfer learning. Bo Wang Haotian Cui ChloeXWang University of Toronto Vector Institute University Health Network

nature.com/articles/s4159…

authors.elsevier.com/a/1ibQx3PtAV8-… Just published review on recent advances in Single-Cell Proteomics. Hope you enjoy!

5th European SCP | 27-28 Aug, 2024 | Vienna, Austria --- apma.at/2023/09/26/5th…
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#prot eomics #prot -conf

New! Online now: Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism dlvr.it/T0Pnjf

7. Datasets don’t come with labels marking what is new and exciting about them. Figuring that out is not simple and cannot be automated. Rather, discovery is an act of self-expression and creativity. Different people will make different discoveries with the same dataset.

Happy to share my recent Current Opinion in Cell Biology Elsevier CellBiology
What is liver zonation? How do hepatocytes organize their activities in the tissue? And what does cell-cell communication and gradients have to do with it?
authors.elsevier.com/a/1iD9i3PA3sV0…

Happy to share our lab's new preprint on a robotic workflow for spatial tissue proteomics sample preparation based on the cellenONE system. Great collaboration with David Hartlmayr and Anjali Seth from Cellenion, led by fabulous Anuar & Di Qin.
bit.ly/414jt6G

🚨conference alert 🚨 registrations are open for the 2024 Mitochondria and Chloroplasts GRC/GRS in sunny Spain! Please apply and spread the word! And for ECR: the majority of the GRS talks are selected from abstracts, so don’t miss this wonderful chance to present your work!!

Same diagnosis, different outcomes? With a precision medicine approach & spatial proteomics Sonja Kabatnik Matthias Mann Lab now report pathways and marker proteins that stratify risk groups for colorectal carcinoma recurrence. Great work, Sonja! medrxiv.org/content/10.110…

Excited to share our latest research on thorough optimisation of phosphopeptide enrichment parameters that also includes Astral MS #phosphoproteomics data ✨
Thanks to Ana Martinez del Val, Patricia Bortel, Ilaria Piga and Claire Koenig.
biorxiv.org/content/10.110…

A resource on tissue-specific expression of mitochondrial proteins and their phosphosites across the mouse. Congrats, Fynn Hansen @labsmann Division of Molecular Metabolism, KI - great work!

Our mapping of the cellular protein #interactome with unprecedented depth is now published @nature. Leaps in robust #proteomics and analytic workflows enabled us to perform over 4.000 pull-downs in yeast unraveling the social and structural aspects leveraging #alphafold multimer.

This is great science. While sharing an office with André Michaelis I've witnessed how thoroughly André combed through this yeast interactome. Have a look at figure 4. Congratulations!!

Fantastic study bridging proteomics and life-saving clinical application. Congratulations Thierry Nordmann and the entire team!

Spatially resolved mapping of proteome turnover dynamics with subcellular precision nature.com/articles/s4146…

The impact (good or bad) that you have on people through your teaching and mentoring will likely be greater than the impact of your research on society.

How does mitochondria sense and control their glutathione levels? Our new work Science Magazine by a fantastic student Yuyang Liu describing a redox metabolite sensing mechanism for mitochondria. Rockefeller University The Mark Foundation for Cancer Research science.org/doi/10.1126/sc…

Excited to announce our lab's first publication, out today Cell Systems.
We are often asked about practical tips and protocols for ultra-low input spatial tissue proteomics. This work summarises key aspects for microscopy + single-cell sensitivity MS 👇bit.ly/3FAHDft

There is no place for antisemitism in this world.