Variable phenotypes and difficult to control functions of vascular #SmoothMuscleCells make it challenging to use them as as seed cells in tissue-engineered vascular constructions.

Scientists aimed to overcome these obstacles using a 3D culture system.

🔗 bit.ly/3y2DK23

Researchers at UPF Barcelona, together with teams of scientists from China, the USA and Spain, produced comprehensive atlas of human skeletal muscle aging!

Check it out in @nature!
🔬 go.nature.com/44g33d6
🗞️ bit.ly/4dbzdL1

📊 Results published in this AJP-Cell Physiology study show that C2C12 cells, unlike skeletal muscle, expressed glutamate dehydrogenase, which competes with glutamic oxaloacetic transaminase for glutamate metabolism.

bit.ly/3wjTPjr

Drs. Jingrui Chen & Zhaokang Cheng's jointly-led research uncovers a novel proapoptotic role for CDK7 in #cardiomyocytes and suggests that inhibition of CDK7 attenuates doxorubicin-induced #cardiotoxicity . WSU CPPS

📍 bit.ly/3w7znSQ

Take a break from research-heavy articles and enjoy this review for an overview of the progress of mitochondrial function regulation in cardiac regeneration! 📚

🔗 bit.ly/3WdT8TA

⚗️ Researchers established both in vivo and in vitro models of hypoxic pulmonary hypertension (HPH) to validate the differential expression of specific markers associated with #hypoxia .

LncRNA MIR210HG is shown to have a role in the progression of HPH.

bit.ly/3xP85Bn

Gather insights about treating atherosclerotic lesions and #restenosis after vascular injury.

Scientists showed that KLF13 promotes vascular smooth muscle cell phenotypic dedifferentiation by directly binding to the SM22α promoter. #VSMC

📍 bit.ly/4d63qey

Time to add some arginine (ARG)-rich foods to your diet! 🥙

Researchers show that ingestion of ARG or ARG-rich foods may alleviate inflammation by attenuating phagocyte invasion in eccentrically contracted #SkeletalMuscles .

🔗 bit.ly/4aGFH2T

📍 Now available in Nucleic Acids Res!

Scientists showed that increased chromatin accessibility due to #telomere shortening resulted in the induction of FOXC1-dependent expression network responsible for contractile dysfunction and #myocardial senescence. 🧬

bit.ly/443pceu

Gain insights into the regulation of #cardiomyocyte mitochondrial metabolism with this Circulation paper and a short tweetorial!

A research team from Kyoto University examined the mechanisms by which myopathy and dilated #cardiomyopathy (CM) develop.

They showed that HOIL-1L is an important intrinsic regulator of cell cycle-related myotube and CM maturation and cell proliferation.

go.nature.com/3UoOz7F

Are you a fan of atlases? 🗺️

Then add this human skeletal muscle aging atlas to your list.

Nature Aging | go.nature.com/4420ueC

Resistance training 🏋️ has shown potential in ameliorating #hypoxia -induced #SkeletalMuscle atrophy in rats, with miRNAs emerging as key 🔑 regulators in this context.

More on this: go.nature.com/3UktNpt

🏁 Start your week with a review of the development of novel treatment options for individuals affected by muscular atrophy!

bit.ly/3PZBmPZ

Congrats to Dr. Jean-Sébastien Hulot (Jean-Sébastien Hulot) and colleagues on their new eLife - the journal paper! 🎉

They developed an assay for fast, reproducible, and high-throughput generation of 3D #CardiacRings around a deformable optically transparent hydrogel.

bit.ly/3xwXbjB

The 1st astrobiological study on the China Space Station (Chinese Space Station) is complete! 🚀

It shows that intervention of thiamine-modified metabolic reprogramming in cardiomyocytes during spaceflight could be a countermeasure against #microgravity .

🔗 go.nature.com/43YxeWa

New work from researchers at Fudan University has investigated the role of integrin α5β1 and FAK in patients with acute type A #AorticDissection , as well as the potential underlying mechanisms.

Read the paper: bit.ly/4avzuXe

Check out this new study in Circulation from the lab of Dr. Roger Foo (@TheFooLab) at NUS!

It identifies asparagine synthetase as a unique molecular marker well correlated with cardiomyocyte dedifferentiation, as well as an essential mediator.

🔗: bit.ly/3VVEIY8