3 years of work... the JUMP-Cell Painting Consortium has now released the world's largest public Cell Painting dataset!

117,000 compounds, 13,000 overexpressed genes, 8,000 gene knockdowns, w/images and extracted profiles 🤯

Data @ Cell Painting Gallery: github.com/jump-cellpaint…

I follow Daniel J Drucker. He highlights papers that I’ve missed, and he often alerts me that my own papers are now online.

WRISG + Levine-Riggs meeting. It’s going to be a week full of amazing science.

Great to see this out! Vikash Chandra and Hazem Ibrahim were able to pinpoint a specific role for TYK2 in controlling the endocrine progenitor cell cycle. Collaborative effort within INNODIA supports the use of TYK2 inhibitors for T1D prevention. rdcu.be/cYkB2

Proud to present my latest work with Mark Dawson investigating how transcription factors and core promoters influence the mechanisms of transcription

biorxiv.org/content/10.110…

Results described below 👇🧵

Our Special Issue on Modelling Development In Vitro is filling up, including a timely Review on ‘Stem cell-based models of early mammalian development’ from @aidanhterhune, Jianping Fu and colleagues.

journals.biologists.com/dev/article/14…

New from Patrick MacDonald Anna Gloyn Mouse and human data reveal the importance of the zinc finger transcriptional regulator Zmiz1 for β-cell function #islets #insulin #diabetes Molecular Metabolism #GWAS #Genetics sciencedirect.com/science/articl…

Now that we are back to mostly in person seminars, I have had pizza three times this week.

A great start to the SRP Research Symposium. Anna Gloyn gave us her top 10 suggestions for early career researchers.

LSI Paper of the Day☀️

Using live-cell imaging & scRNAseq, Jamie Chu, Honey Modi, Nicole Krentz & co-workers identified transient, fluctuating maturity states in pancreatic β-cells marked by Ins2 gene activity. Published in ADA Professional Publications. @jimjohnsonsci lab.

bit.ly/3yVCiMB

Pizza solves everything!

Interesting thread on how to hive mind problem solving.

Manhattan plots highlighting GWAS genes that are targets of approved drugs. Nice!

From a preprint 'Using genome-wide association results to identify drug repurposing candidates' by Nathaniel, Emil Danielle and colleagues.
medrxiv.org/content/10.110…

This is kindest, most meaningful and humbling thing a person could ever say about a coworker. I am so touched by this blog ⁦Maryann KoopmanKelly⁩, we miss you too!!

A good win – View From an Irish Back Yard maryannk.wordpress.com/2022/10/13/a-g…

It’s been nearly 15 year of having the privilege to lead my own research group. In this time I’ve had many wonderful scientists pass through. I’ve learned a lot about not just leading a group, but also being a good mentor to younger scientists. While I have not always made 1/

What a great article Dr. Miranda Stratton, PhD (she, her)

ASCL1 interacts with the mSWI/SNF at distal regulatory elements to regulate neural differentiation biorxiv.org/cgi/content/sh… #bioRxiv

Happy Thanksgiving 🇨🇦🍁