Early this year, we learned about recurrent de novo mutations in a small nuclear RNA (snRNA) gene (RNU4-2) as one of the most common causes of neurodevelopmental disorders (NDD). Well, it appears that it might be just the tip of the iceberg of snRNA gene mutations causing NDD.

Another landmark study from Ashi Weeraratna and colleagues. Congratulations!! ————Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy: Cell cell.com/cell/fulltext/…

Mutations in the U2 snRNA gene RNU2-2P cause a severe neurodevelopmental disorder with prominent epilepsy #RareDisease #Genetics #morbidgene medrxiv.org/content/10.110…

The final version of is now published: nature.com/articles/s4146… Congratulations Matvei Khoroshkin and our team across 3 groups, ours, Faraz K Mardakheh, and Vanja (Ivan Kulakovskiy)!

Excited to see this work out led by former PhD student Sydney Conner where we have looked at the temporal changes in the ECM of mammary glands during weight gain driven by obesity - to better understand how increases in weight contribute to invasion and metastasis.

Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles coated with the fusogenic FAST protein: Cell cell.com/cell/fulltext/…

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Two studies of more than 100,000 women have revealed a suite of genes that help to regulate when a person enters menopause, and influence their cancer risk go.nature.com/4e0s8wE

Now online! Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket dlvr.it/TD8BsX

Precision oncology across the ages: Impact on children, adolescents, and young adults dlvr.it/TD8TQk

Online Now: Spatial omics advances for in situ RNA biology dlvr.it/TD8Y9t

The anti-aging impact of metformin (randomly assigned, with controls) in male monkeys after 40 months of treatment, a pan-omic clock assessment —~6 year regression of brain aging, with prevention of atrophy and enhanced cognitive ability —minimal effect on blood sugar —evidence

New paper from our lab! Logan Schwartz defines the molecular signatures of Oncostatin M signaling in hematopoietic stem cells... both OSM receptor dependent and independent! We really hope these RNA-seq datasets will be useful for others in the field. rdcu.be/dTLkA

Exciting collaboration with Tima Karginov from the Vella lab UConn Health on poison exons in T cells biology #splicing #rna #immune The Jackson Laboratory

Ziegler's lab was among the first to investigate Foxp3 in T cell function but mistakenly created a transgenic Foxp3 mouse instead of a knockout mouse, losing out to Rudensky’s lab, which produced the #Foxp3 KO mouse and gained recognition. #Immunology academic.oup.com/intimm/advance…

Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response dlvr.it/TDJCDJ

We are excited to help spread the word about the upcoming EACR virtual conference on Cancer and Ageing (December 3-4, 2024). Register & learn more here:  eacr.org/conference/can…… Abstract Submission Deadline: Oct. 14

Open RFP: The Mark Foundation's Drug Discovery Award program is accepting letters of intent! This grant offers up to $1M in funding to discover & progress a new therapeutic agent into preclinical development. themarkfoundation.org/drug-discovery… #drugdiscovery #researchfunding

🚨Excited to share another paper in Molecular Cell!🚨 In collab w/ Columbia University’s Marko Jonvanoic, Lena Street, & @HoustonMethodist’s Kris Brannan, we mapped RNA-aware, RBP-centric protein-protein interactions (PPIs) across the mRNA life cycle in human cells! cell.com/molecular-cell…

Thank you to The Mark Foundation for Cancer Research for co-sponsoring the special workshop on aging & cancer featuring an esteemed panel of experts: Vishwa Deep Dixit Nir Barzilai Olga Anczukow Payel Sen and Ines Fernandez Maestre. The presentations / discussion will guide future research projects.