🚨FREE LINK to our latest review on metabolism of tissue macrophages depending on LOCATION AND AGE: authors.elsevier.com/a/1j6Zt3jDgWq3… Tissue-resident #macrophage #metabolismis diverse across organs to support distinct tissue functions. #Aging deregulates this balance: #inflammaging

Please check out our new paper led by postdoc Dongliang Lu. We report that liver-specific KO of ACOX1 increases circulating levels of #omega3 VLCFA THA (C24:6) and HHA (C26:6) that promote adipose browning and decrease inflammation by activating GPR120. nature.com/articles/s4146…

Macrophage-Myocyte dance in engineered microtissue 🤩 Congrats on the cool cover art by Nature Cardiovascular Research for Homaira Hamidzada Slava Epelman paper.

Congrats to Saifur Rahman Khan of Dr. Babak Razani Lab Vascular Medicine Institute VA Pittsburgh for winning First Place (Early Career Investigator) at symposium celebrating 2024 #VAResearch Week. Stay tuned for his metabolomics in #Diabetes discoveries. Impressive breadth of VA Research in Pittsburgh today👏👍

Noam Chomsky on ChatGPT: He’s not wrong.

Checkout the new review in Nature Cardiovascular Research on #immunometabolism in CVD by Prof Andrew Murphy Dr Andrew Fleetwood @DrJnoonan from Baker Institute in collaboration with 💮Nicole La Gruta Monash Biomedicine Discovery Institute and KalliesLab Doherty Institute nature.com/articles/s4416…

Always interesting when more evidence arises for #atherosclerosis #CVD in ancient mummies (i.e. not just modern Western diet issue). Nice work by Randall Thompson from Saint Luke's Mid America Heart Institute and international colleagues showing even severe plaques at age 30s-40s. academic.oup.com/eurheartj/adva…

Beautiful work from Martin. Jastroch lab in Science Magazine on evolution of UCP1 in #adipose #thermogenesis from marsupials to mammals. Also superb editorial by Katharine Grabek & Sprenger. Two-stage evolution of mammalian adipose tissue thermogenesis | Science science.org/doi/10.1126/sc…

Welcome to 3 new members of the Dr. Babak Razani Lab. Carlos Cosme (Carlos Cosme Jr.) is Pitt/CMU MSTP Graduate Student; Doureradjou Peroumal (Doureradjou Peroumal) and Jun Huang are new Postdoctoral Fellows. Fair to say this team is eager to get some cool metabolism projects started... 🤩💪

Kudos to Efeyan Lab for the study in Nature Aging characterizing RagC mutant mice to active #mTOR, #inflammaging, and shorten #lifespan. Mechanism involving myeloid cells including hints of TFEB & #lysosome suppression suggests lots of cool followup work. nature.com/articles/s4358…

Excellent and clever study by Budin lab (Itay Budin) in Science Magazine figuring out how membranes of organisms like jellyfish can withstand massive pressures in the deep sea. Guess what? Implicates one of our favorite #phospholipid classes, #plasmalogens! science.org/doi/10.1126/sc…

Nice work by Daniele Lettieri Barbato lab in Cell Reports on role of lipid-associated #macrophage (LAM) and extracellular vesicles in Brown Fat #BAT during #obesity. The role of LAM in Brown Fat understudied and more work like this needed to get clear picture. cell.com/cell-reports/f…

A great and timely read in Molecular Cell reviewing cutting edge concepts of phase separation and biomolecular #condensates in the #macrophage and other innate immune cells. cell.com/molecular-cell…

Congratulations to Xiangyu Zhang Saifur Rahman Khan Ali Ajam of @Razanilab in partnership with Anum Saeed for being awarded two Vascular Medicine Institute McKamish Family Foundation Cardiovascular Innovator Awards on projects studying #cholesterol & #mtor and de novo #ceramide synthesis in #CVD 👏

Excited to share our latest study on cross-species scRNA-seq of atherosclerotic plaques: academic.oup.com/cardiovascres/… We reveal key differences in the atherosclerotic immune cell repertoire between humans and mice. #Atherosclerosis #scRNAseq #Immunology 1/n

Congratulations to PittDeptofMed Pitt Health Sciences and new Editor-in-Chief Oliver for being awarded editorial oversight by ASCI for JCI insight. Looking forward to working with this talented group of physician-scientists on the Editorial Board. health.pitt.edu/news/asci-sele…

Great to see this nice work by newly minted Dr. Richa Banerjee from YangLab on role of #mTOR/ mTORC2 & Akt-FoxO signaling in #lymphatic valve development ATVB: An AHA Journal. Also a pleasure serving as external chair of her thesis defense University of South Florida. ahajournals.org/doi/10.1161/AT…

Always exciting when one of our favorite #autophagy chaperones, p62/SQSTM1, is implicated in novel ways. In this case, key role in micronuclei seen with chromosome instability of #cancer cells. Great work by Stefano Santaguida lab in Science Magazine. science.org/doi/10.1126/sc…

If there was any doubt how critical #lipids and #inflammation are to #CVD, take a look at the work of Dr. Paul Ridker and colleagues in NEJM that measuring only the trio of LDL-C, Lp(a), & CRP predicts MACE a full 30 years later in a cohort of U.S. women! nejm.org/doi/full/10.10…

Excellent series that Nature Metabolism has started on #diet #nutrition and #metabolism #CVD. Informative papers on current issue including the one on #precisionnutrition using serum biomarkers. nature.com/articles/s4225…