In the grant: 'We will use tool X to analyze data A because it ranked amongst the best-performing tools in multiple benchmarking studies [1-4]'

In reality: 'Imma use tool Y because I can install it, it's user-friendly and my buddy developed it'

+ Hey bro, how should we name this really interesting gene that we just discovered?
- What about 'really interesting new gene 1A'?
+ Damn, it really has a RING to it
- Say no more

🔥 story lead by Michael Scherer & Indranil Singh, with Alejo Rodriguez-Fraticelli, PhD: epimutations stably mark clones in hematopoiesis over months and years, and can be read out at scale using targeted single-cell, single-CpG-resolution profiling of DNA methylation🧵biorxiv.org/content/10.110…

When a Harvard professor takes a sabbatical at Karolinska:

Ramon Massoni Badosa Consider this figure (Figure ED9) from nature.com/articles/s4158…. Years ago we developed a nucleotide differential test for TF foot printing.

Very HAPPY to finally see FIX&CUT out!🤩

👉🏼 Enabling sample fixation followed by tissue dissociation without stressing the cells.
👉🏼 Promoting flexible, collaborative, and multi-center clinical research studies.

📢 Stay tuned. Tweetorial coming up soon!
doi.org/10.1186/s13059…

Heidelberg, always in my ❤️