Preprint alert📣📣Excited to share our new method SCENT to create accurate enhancer-gene map from #singlecell #multiome data with Soumya Raychaudhuri সৌম্য রায়চৌধুরী! SCENT using multiome technology is very powerful in defining disease causal variants & genes in #GWAS #ASHG22
medrxiv.org/content/10.110…

Interested in leveraging multimodal single-cell data to interpret GWAS signal in in the context of autoimmune disease heritability? If so, I'd love to have you join for my talk at 2pm this afternoon at #ASHG22 ! Grateful to pursue this work with Soumya Raychaudhuri সৌম্য রায়চৌধুরী Tiffany Amariuta ++

#ASHG22 📣📣Today I am super excited to present our new statgen method to create accurate enhancer-gene map from #singlecell #multiome data! I’ll show how it is powerful in fine mapping disease alleles in #GWAS 🙂Join us at 10:45am Room515!!🙌

#ASHG Interested in the genetic regulation of HLA expression? Come check out our single-cell eQTL study of more than 1.14 million immune cells today at 3pm (PB2635)! 🧬
w/ Soumya Raychaudhuri সৌম্য রায়চৌধুরী Yang Luo Saori Sakaue + others

10/These results suggest that the landscape of changing gene regulation in dermal and epidermal cell types may be an important component of #psoriasis , and that dermal and epidermal genes may be therapeutic targets.

9/The most significant SPITS interaction eQTL was rs1491377616-LCE3C. The SNP is associated with psoriasis genetic risk and it colocalizes with the psoriasis risk allele. This gene is specifically expressed in keratinocytes. Increased inflammation magnifies the effect of the SNP.

8/Intriguingly, most eQTLs modulated by local skin inflammation in psoriasis are expressed in dermal and epidermal cell types and not immune cell types. We observed that most SPITS-interacting eGenes are skin cell-specific (62/84) rather than immune cell-specific.

Looking forward to having you back in Boston , Mark!

The tire industry probably got inspired by HLA nomenclature. 🤷🏻‍♀️

thank you for the warm welcome :)

Don’t miss this talk if you are interested in immunogenomics!

US PIs - Does your organization have newly enforced regulations about hiring Iranians? We were informed that due to the 'changing geopolitical environment' an Export License and Technology Control Plan is now required for recruitment from Iran and a few other countries. 1/6

Thanks for the shoutout Cornell College of Veterinary Medicine! Cornell CVG was delighted to partner with Cornell Center for Immunology to pull off the first Immunogenomics Symposium @Cornell. Congrats again to all trainees who were selected to speak and who wonder poster awards!
vet.cornell.edu/news/20221006/…