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Non-canonical IKKs side with N4BP1 against the family dlvr.it/T74PbS

Our review by Dr Andrew Fleetwood Jonathan Noonan 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇪🇺🦦 KalliesLab 💮Nicole La Gruta is now out in Nature Cardiovascular Research ! All the latest on #immunometabolism in CVD. This field keeps evolving, so much to discover! link.springer.com/10.1038/s44161…

Our latest findings: Mislocalized TREX1 causes DNA damage in flies, mice, & humans with RVCL, a mimic of lupus and radiation injury—plus high odds of breast cancer ⁦PennRheum⁩ ⁦Brain Research Institute, Niigata Univ⁩ ⁦Penn Medicine⁩ ⁦Nature Communications⁩ nature.com/articles/s4146…

1/ Increasing vaccine protection against #COVID. A/Prof Sylvie Alonso’s Group NUS & A/Prof Mireille Monash Biomedicine Discovery Institute have discovered a technique for prolonging immune response to #SARSCoV2 virus in pre-clinical models using an antibody construct. More: bit.ly/3yKN3Ek

A vaccine that is effective in the elderly. Pleased to share our study on the use of hyperactivator adjuvants to stimulate anti-tumor immunity in the young and old. All other vaccine adjuvants, and even checkpoint inhibitors, failed to do so. cell.com/cell/fulltext/…

I am incredibly excited to share our work on the diverse mechanisms and functional responses of type I interferon adaptors via pLxIS motifs! authors.elsevier.com/c/1jJz73vVUPRm…

Move over STING, TRIF and MAVS. IRSp53 and GMIP join the club of pLxIS proteins that stimulate interferons. So pleased to share our new study, which used synthetic biology to reveal multiple mechanisms that lead to anti-viral immunity. With a surprising link to metabolism.

All credit goes to the fantastic Lauren Landau, who led this work from its infancy. Many thanks to the collaborators who supported this work. Link to the full text: authors.elsevier.com/a/1jJz73vVUPRm…

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

The first paper from the Chen lab is out! Congrats See Jie Yow on dissecting the cell type-specific requirements for Yersinia-induced pyroptosis in neutrophils and macrophages! rdcu.be/dMNeZ

Now in Science Immunology: CrowLab & Casanova Lab #review the #human monogenic disorders underlying insufficient & excessive type I #interferon signaling. These disorders may inform prevention & treatment of #viral & #inflammatory #diseases! #IFN #PID bit.ly/SciImm_adm8185

1/8 How can we enrich cells with a defined transcriptional state, but without killing them? Please read on! biorxiv.org/content/10.110…

Also! I'm recruiting for a... Post doc: aurecruitment.actionhrm.com/myrecruit/newA… And an RA: aurecruitment.actionhrm.com/myrecruit/newA… If you're interested in discovering weird and wonderful triggers of inflammation in #neurodevelopmentaldisorder, #neurodegeneration and #inflammatorydisease please apply

IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1 iScience journal cell.com/iscience/fullt…

I'm very proud to have co-authored this review on antibodies and infection with my twitterless PhD student Tyron Esposito, The TWells Lab and Ian Henderson. Please check it out 👇 Mechanisms of antibody-dependent enhancement of infectious disease | Nature Reviews Immunology

New paper collaboration with the Cullen lab. Peter J. Cullen led by Rebeka Butkovič, Alex Walker and Michael Healy. Here we identify the mechanism by which SNX17 mediates cargo recruitment to the Commander complex for endosomal trafficking. nature.com/articles/s4146…