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Another step to crack the role of PTMs in regulating gene expression; published today ACS Central Science pubs.acs.org/doi/epdf/10.10… Another great collaboration with the Ariel Afek 💔 group. Congratulations to Nithun, Yumi, and the rest of the team!

"Site-Specific Acetylation of the Transcription Factor Protein Max Modulates Its DNA Binding Activity" Raj V. Nithun, Yumi Minyi Yao, Omer Harel, Shaimaa Habiballah, Ariel Afek, and Muhammad Jbara pubs.acs.org/doi/epdf/10.10…

A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins. Exciting collaboration with LashuelNeuroLab to decipher the role of aromatic PTMs in regulating α-Syn aggregation and pathogenicity. chemrxiv.org/engage/chemrxi…

Thrilled to share our latest work in nature in collaboration with the Davis Group at Rosalind Franklin Institute & Oxford Chemistry. We developed a 'cap & glycosylate' strategy that directly transforms native sugars into glycosides & glycoproteins! NUS Chemistry #glycotime nature.com/articles/s4158…

Not easy to cage NIR photosensitizers but ZhiMing Cheng did! First proof of concept with cathepsin-triggered PS but a modular platform in principle compatible with many other targets and in vivo use. Check it out Angewandte Chemie! Free link: onlinelibrary.wiley.com/doi/10.1002/an…

Happy to share this work by Elise Ficaretta demonstrating that ncAA incorporation in E. coli using an endogenous tyrosyl-tRNA/synthetase pair is remarkably more efficient (up to 10 contiguous ncAAs) than a foreign pair pubs.acs.org/doi/full/10.10…

Our work, which shows the first P-center that can activate the H-H bond through an oxidative addition type reaction and be used for catalytic hydrogenation—unprecedented for single main group centers—is now published in Nature Chemistry. doi.org/10.1038/s41557…

A focused library of site-specifically acetylated Max transcription factor analogs was chemically synthesized to dissect the role of Lys-acetylation in its DNA binding activity NEW #ASAP by @jbaram90 @afek7afek Read it here: go.acs.org/a9D

Happy to tell that our our startup, Medical Diagnostics Company, JaxBio Technologies, Secures €2.5 Million Grant from European Innovation Council Accelerator prweb.com/releases/medic…

Happy to share our new paper in Nature Chemical Biology! Photoproximity labeling of endogenous receptors in the live mouse brain in minutes nature.com/articles/s4158…

Our new paper on geometric deep learning of protein-DNA binding specificity and DeepPBS method out Nature Methods. Work led by USC Dept. of Quantitative & Computational Biology PhD student Raktim Mitra, w/contribs by rohslab.org members & Cameron Glasscock. USC Research USC Dornsife College of Letters, Arts & Sciences USC nature.com/articles/s4159…

Happy to share our latest work on the C-Selective Ring-Opening of Phosphiranes with Carboxylic Acids and Other Nucleophiles, which was published today in Angewandte Chemie . Huge congratulations to Avisek, Van, and Corentin! onlinelibrary.wiley.com/doi/10.1002/an… Laboratoire Hétérochimie Fondamentale et Appliquée CNRS Chimie

The next chapter in fluorescent antifungal probes is here! We reveal new insights into antifungal azole probe uptake patterns. Discover how distinct fluorescence can enhance resistance diagnostics and differentiate between Candida species! pubs.acs.org/doi/10.1021/ja…

Thrilled to share our latest work on the late-stage, site-specific chemical insertion of aromatic PTMs into proteins, published today in J. Am. Chem. Soc. A big thanks to LashuelNeuroLab for the exciting collaboration. Congratulations to Lin, Shaswati, and the team! pubs.acs.org/doi/10.1021/ja…

Stereoselective C-B and C-H Bonds Functionalization of PolyBorylated Alkenes (Ahmad Masarwa and co-workers) Ahmad Masarwa (Masarwa Lab) #OpenAccess onlinelibrary.wiley.com/doi/10.1002/an…

A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins | Journal of the American Chemical Society @telavivuniv EPFL #Posttranslational #Modification #Chemical #Protein pubs.acs.org/doi/10.1021/ja…

@Dynafluors and BOOMchemistry.com joined forces to design a universal caging strategy to control singlet oxygen generation. Bioorthogonal, bioresponsive, and working in most photosensitizers! Fantastic team effort. Free link ▶️ rdcu.be/dSStz B&BSymposium

We are hiring! Position open for a new assistant professor in the Department of Biophysics & Biophysical Chemistry in Johns Hopkins Medicine . Considering all areas in experimental and computational biophysics. Please spread the word. apply.interfolio.com/154014