It was great fun to use #signor data to decipher TKI-therapy #resistance mechanisms in FLT3-ITD positive #AML patients! I have such amazing collaborators!! Francesca Sacco Veronica Venafra Giorgia Massacci Martin Boettcher monia pugliese Natalie Krahmer biorxiv.org/content/10.110…

Our paper is online!! #SignalingProfiler is a novel method that allowed us to discover the key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients nature.com/articles/s4137…

Very proud to share this work of my group where we integrate #phosphoproteomics and our #signalingProfiler pipeline to unveil chemoresistance in #AML in collaboration with Livia Perfetto , Martin Boettcher and the haematological group @madgeburg!nature.com/articles/s4137…

Up next is Veronica Venafra from Francesca Sacco lab who showcases her computational strategy to produce context specific networks of intracellular signalling, namely Signaling Profiler (available online!)

Great science and amazing people in #SysBioCurie23 at SysBioCurie

Very happy to have shared my #PhD project at #SysBioCurie23 about #SignalingProfiler, an R package to integrate multi-omics data and prior knowledge and create mechanistic models 🧬💻💪

Last day at SysBioCurie, a short visiting full of great ideas and fruitful collaborations. Thanks a lot 💻🧬

Merry Christmas from us :)!!!

Our manuscript is out! nature.com/articles/s4138… Proud of our curation effort to annotate #SFARI genes and #AutismSpetrumDisorders pathways in #SIGNOR! I am so grateful to all my collaborators, MartaIannuccelli, Alessandro Vitriolo, Gianni Cesareni, Giuseppe Testa et al! It was great!!

We are Hiring!!! 👇 We are actively seeking highly motivated and qualified individuals for Post-Doctoral and PhD positions in the field of bioinformatics and computational biology.

Our essay in Nat Cell Bio: "Bringing computation to biology by bridging the last mile" We argue to shift resources/rewards towards creating user-friendly software to bridge computation and biology-it yields huge returns! Shantanu Singh Free author link: rdcu.be/dv82F

SignalingProfiler 2.0: a network-based approach to bridge multi-omics data to phenotypic hallmarks biorxiv.org/cgi/content/sh… #biorxiv_sysbio

Proud to share this new story from my group and Livia Perfetto’s team. Here we generate genotype specific predictive models of TKI resistance in FLT3 driven AML! Congrats Sara Latini Veronica Venafra!! doi.org/10.7554/eLife.…

Veronica Venafra now at #BITS2024. This presentation will explore how SignalingProfiler integrates multi-omics data to identify phenotypic hallmarks, facilitating new approaches in drug repurposing. #Bioinformatics #MultiOmics #DrugRepurposing

Happy to share our work in collaboration with Tommaso Schirinzi, Maria Wahle and Maxi Zwiebel from Matthias Mann Lab, Livia Perfetto and Veronica Venafra. Here, we show that blood cells, from Parkinson disease patients, display a stage-dependent remodelling of their phosphoproteome.

🚀 Unlock the hidden signaling pathways within your multi-omic data! 🔬 SignalingProfiler 2.0 predicts protein activities and phenotypes and maps them into an intuitive network. 🧬 nature.com/articles/s4154… #SystemsBiology #Multiomics Livia Perfetto Francesca Sacco Veronica Venafra