Research Highlight | Grune et al. in Circulation show that immune activation in acute respiratory distress syndrome (ARDS) induces shifts in #cardiacmacrophages like those observed in individuals with #COVID19. nature.com/articles/s4416… 👉 rdcu.be/dEx91

Research|Tuz et al report that #stroke and #MyocardialInfarction induce the release of neutrophil extracellular traps (NETs), loss of B cells and reduced IgA secretion, and that inhibition of NETs prevents loss of IgA in patients and mice. Institute for Experimental Immunology & Imaging 👉rdcu.be/dFxfR

Research| Hamidzada et al show that human ESC macrophages are educated into a tissue-resident fate in human cardiac microtissues. #Macrophage incorporation enhanced cardiac microtissue function via #efferocytic ingestion of stressed cardiomyocyte cargo. 👉 rdcu.be/dHjNc

Research| Elevated Lp(a) is an independent #atherosclerosis risk factor not routinely measured. Aminorroaya et al. develop and validate ARISE, a #MachineLearning model to detect elevated Lp(a) using electronic records. 👉 rdcu.be/dHst0

Very excited to share our latest work focused on hPSC-macrophages in human cardiac microtissue function, now published in Nature Cardiovascular Research and featured on the cover! (Ella Marushchenko) Slava Epelman

❤️Our May issue is out❤️ Read about how hPSC-macrophages promote maturation of #cardiac microtissue, discover the #MachineLearning model ARISE to detect elevated Lp(α), find out the current state of #heartrepair using iPSC-based cell strategies and more! nature.com/natcardiovascr…

Review| Fleetwood et al. review the role of immune dysfunction and #inflammation in #cardiovascular disease, exploring immune cell metabolic reprogramming in response to environmental cues. doi.org/10.1038/s44161… 👉 rdcu.be/dITN3

A fantastic Review article Nature Cardiovascular Research on Immunometabolism in atherosclerotic disorders by Prof Andrew Murphy Dr Andrew Fleetwood Jonathan Noonan 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇪🇺🦦 from Baker Institute and 💮Nicole La Gruta Monash Biomedicine Discovery Institute and KalliesLab Doherty Institute rdcu.be/dITN3 #atherosclerosis

Eschenhagen Thomas Eschenhagen and Weinberger Florian Weinberger on the perspectives and challenges of #heartrepair with #iPSC-derived #cardiomyocytes Nature Cardiovascular Research. #cardiacregeneration #stemcells

Couldn't attend the #Immuno-#Cardiology Symposium Foundation Leducq The Jackson Laboratory? No problem-> read the report 'Linking immune modulation to cardiac fibrosis' here 👉 rdcu.be/dIUBP #fibrosis #cardioimmunology

Research| Htet et al. identify and characterize a transcriptional enhancer that regulates #cardiomyocyte maturation and function in #hPSC and mouse models. doi.org/10.1038/s44161… 👉 rdcu.be/dJx6o

Take a look at our new article Nature Cardiovascular Research looking at Regenerative Senescence in Cardiac Repair. nature.com/articles/s4416…

Our June issue is out!

I am attending the #Endothelial Cell Phenotypes in Health and Disease The Global Research Council (GRC) If you want to discuss your projects and future submissions (or vascular biology in general) please contact me!

Fresh off the press Nature Cardiovascular Research. Thankful for the hard work of everyone involved Tufts School of Medicine Tufts University TuftsGSBS Cummings School of Veterinary Medicine 🐕🐈🐴🐄🦅 & Aarti Asnani Abul Ariza BIDMC Department of Medicine #cardioimmunology #cardiooncology #Tcells

Research| Maddeb et al. show that while #HFpEF presents normal-looking contraction, the muscle looks abnormal, with disrupted contracting proteins, mitochondria and excess fat, particularly in the most obese patients. 👉rdcu.be/dPlJ7

🚀 Thrilled to share our new publication in Nature CVR! We revealed the crucial role of a newly described APOE+ valve interstitial cell subtype in human valve remodeling. Huge thanks to our amazing collaborators! 🙌 Jason Spence Ya-Wen Chen YutzeyLab Simon Miao

Research| Shetty et al report that a favourable #cardiovascular risk factor profile may partially offset the risk of #HeartFailure and atrial fibrillation among carriers of high-proportion spliced-in Titin truncating variants. doi.org/10.1038/s44161… 👉 rdcu.be/dPNgq

Research| Sarig & Tzahor et al. show that the #MultipleSclerosis drug, glatiramer-acetate, improves cardiac function and reduces scar area in rodent models of acute #MyocardialInfarction and ischaemic heart failure. doi.org/10.1038/s44161… 👉 rdcu.be/dR9YV