Another PW lab paper for you! Here, in Cell Reports we report that SRSF7 is unique amongst SR proteins in its ability to activate antiviral immunity. It does so by directly activating transcription of IRF7, a master regulator of the type I IFN response. cell.com/cell-reports/f…

Feb 29th, Rare Disease Day, is dedicated to raising awareness about rare diseases and their impact on people worldwide. This includes individuals affected by mitochondrial diseases that affect the mitochondria which are responsible for producing energy in cells.

Two weeks left to register - join us in Poland to see talks by our fantastic list of speakers!

I’m extremely proud of my PhD student Jordyn Van Portfliet for her hard work and dedication. Jordyn’s NRSA F31 application, which aims to characterize innate immune dysfunction in models of mitochondrial DNA disease, was funded today. NIAID Funding TAMU Genetics and Genomics The Jackson Laboratory

LIGHT EVERYTHING RED FOR NC State Men's Basketball AND NC State WBB 🐺🏀 HEADING TO THE FINAL FOUR! 🐺🚨 #GoPack

Thank you Graef Lab for hosting my visit to Cornell Mol Bio & Genetics. Great people and science!

🎉 Congratulations to the 2024 recipients of The Jackson Laboratory Cancer Center's Brooks Scholar Award: Drs. Abate Bashaw, Maeva Devoucox and Rama Ramasamy! This fellowship for postdoctoral associates at The Jackson Laboratory supports research at the intersection of #aging and #cancer.

👏 Celebrating Ph.D. trainee Jordyn VanPortfliet! Jordyn is a visiting Ph.D. candidate from TAMU Genetics and Genomics, working in the A. Phillip West at The Jackson Laboratory. She was recently awarded an F31, "Targeting the Nrf2 axis to reduce lung immunopathology in PolG-related mitochondrial disease."

If you are interested in Aging and Immunity, we have a fantastic (and affordable) hybrid meeting coming at the end of June. Abstract submission is open for short talks and posters! jax.org/education-and-…

Check out the latest review issue in Human Molecular Genetics focused on all things mitochondria! Great to work with ShuttLab and our trainees to provide an update on mtDNA in innate immunity.

Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain jbc.org/article/S0021-…

Just returned from the #EMBOmitochondrialGene meeting. Great talks, posters, & networking. The excursion to Warsaw Old Town and the Gala dinner were especially cool! Thanks to NCL mtDNA, Hauke Hillen, Joanna Rorbach, and Roman Szczesny for organizing!

Thank you to everyone that joined last week's EMBO meeting on mitochondrial gene maintenance and expression - for sharing your data and for all of the great discussions. We hope you enjoyed it as much as we did!

Delighted to share the last study of the lab led by the fantastic postdoc Luis Carlos Tábara Rodríguez out in Cell !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. MRC MBU Cambridge University authors.elsevier.com/sd/article/S00…

The work of Xiaoxu Li and collaborators defines a simple continuous and composite trait, termed the metabolic health score, that is more accurate in defining metabolic homeostasis and predicting future disease incidence sciencedirect.com/science/articl…

📘 New Review in Human Molecular Genetics, "Mitochondrial DNA release and sensing in innate immune responses" with Jordyn Van Portfliet & A. Phillip West: bit.ly/4bYeZD9 #jaxresearch

Very excited to share our paper outline a new role for on Cytotoxic T-cells in anthracycline cardiotoxicity out today in Nature Cardiovascular Research nature.com/articles/s4416…

Hello everyone, the new season of MITOtalks is ready to roll, and we have some awesome MITOscience waiting.

Why do we itch? Ask your immune system, and Dr. Sokol and colleagues. They provide a simple and elegant answer to this timeless question. Kudos to the authors on this fascinating discovery. nature.com/articles/s4158… Caroline Sokol MDPhD Harvard Medical School

It was awesome hosting Dr. Raquel Sitcheran via the The Jackson Laboratory Cancer Center Visiting Scientist Program. We made significant progress on collaborative projects related to macrophage immunometabolism and non-canonical NF-κB signaling in cancer. Thanks The Jackson Laboratory for your support!