🆕PUBLICATION

FCoV-23 causing FIP in a cat imported to the UK from Cyprus

The Roslin Institute Dr. Amanda Warr 🧬 Christine Tait-Burkard

Read more below ⤵️⤵️

pubmed.ncbi.nlm.nih.gov/37975439/

P681. A KEY MUTATION in Alpha, Delta and Pirola
(mega-thread)

To address the pressing challenges facing humanity that stem from the unsustainable & inequitable ways that we interact with the environment and each other, we've launched two brand new concentrations for the Fall 2024 semester! Read more from Cornell University College of Veterinary Medicine: bit.ly/3MMxVKR

New preprint! I will try to keep this summary lay-friendly. Recently a viral outbreak started in Cyprus with a high number of cats showing clinical signs of feline infectious peritonitis (FIP), and it is estimated that over 8000 cats had died by mid-July.

biorxiv.org/content/10.110…

Very interesting study, showing how mutations arise randomly upon long serial passage of #SARS2 . What's interesting to me is that it again shows how unstable the FCS is - it's scrambled in all lines, even without immune pressure. 1/3

biorxiv.org/content/10.110…

Delighted to share our article nature identifying TMPRSS2 as a functional receptor for seasonal #coronavirus HKU1.
Congrats to Saunders Nell Julian Buchrieser and wonderful collaborators from INSTITUT PASTEUR and Amsterdam UMC
nature.com/articles/s4158…

Delighted to see our piece on the last 1.5 year of SARS2 evolution out now in Nat Micro. Really great collaboration between variant trackers and academics including many involved with Pango Network News nature.com/articles/s4156…

Happy to share our most recent preprint on SARS-CoV-2 and the role of S on virulence. Great job of outstanding people in my lab. #MathiasMartins , #MohammedNooruzzaman , #JessieLeeCunhingham
biorxiv.org/content/10.110…

Lovely targeted review by Sarah Caddy & colleagues on the role of non-neutralising antibodies in protection from viral disease - it's not just about the neuts! journals.plos.org/plospathogens/…

Nature research paper: Sialoglycan binding triggers spike opening in a human coronavirus go.nature.com/45ckfiE

Nanopore R9 had limitations in resolving low-complexity regions e.g. hemagglutinin cleavage site. R10.4.1 = increased data output, higher average quality ,lower minor pop insertion & deletion freq. For the cleavage site, R10.4.1 90% resolved.
👉biorxiv.org/content/10.110…

Nipah virus outbreak contained, no source identified yet

Check out our latest review on viral membrane fusion. Please see extra information & Refs. in the Supplemental dataset and Supplemental legends. Thanks to A. Ward, L. Odongo, and L. Tamm for help with this. annualreviews.org/doi/10.1146/an…

This is not a 🧵: this is the most clear and updated review on SARS-CoV-2 cell entry I have ever read.

Survey of white-footed mice in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses biorxiv.org/cgi/content/sh… #biorxiv_ecology

sciencedirect.com/science/articl…
New canine CoV strain causing outbreak (thousands of deaths in 3 years) in Chinese Fox fur farms. The 15 genomes show good diversity, somewhat contradicting the epidemiological findings, so origin of the outbreak is unclear.

New research from Cornell University College of Veterinary Medicine used engineered mice to compare #SARSCoV2 #Omicron subvariants, and found BA.5 was more virulent, likely due to its ability to rapidly replicate early during infection. Science Advances Baker Institute Krishna Ramanujan news.cornell.edu/stories/2023/0…

📄 📄 Our molnupiravir work is now out after peer-review! We definitively demonstrate that molnupiravir has resulted in viable SARS-CoV-2 viruses with significant numbers of mutations, in some cases with onwards transmission of mutated viruses. nature.com/articles/s4158…

We developed a method to monitor single virus particle fusion with endosome membranes and found a 2nd role for cathepsins in Ebola entry. Should be useful for studies of any endosome-entering virus (or toxin). Kudos to newly minted Dr. Odongo and team. pubmed.ncbi.nlm.nih.gov/37728342/

The updated #COVID19 vaccine is free.

Whether you are uninsured or have health insurance, you can get a free vaccine. Vaccination remains the best protection against serious COVID-19-related illness.

Find an appointment near you at vaccines.gov 📍