Last year I taught myself R with resources I primarily found via Twitter. I've been meaning to share some of the resources here, and I finally have a little time today. So here they are... 🧵

Academic Chatter™ #rstudio #rstatistics

Obesity in #DELIVER a/w markedly ↑ risk of worsening HF & substantially worse NYHA class & QOL vs normal/overweight pts. A clear pathway of risk!

These obese individuals derived similar ↓ in clinical events & greater QOL benefit w #SGLT2i dapagliflozin

academic.oup.com/eurheartj/adva…

Who to screen for ATTR-CM? A simple score to guide you! Up to 35% males in #HFpEF trials w/ high risk score! Dan Davies, MD Omar AbouEzzeddine MDCM, MS (He/Him/His) Sanjiv J. Shah, MD Yogesh Reddy Martha Grogan MD Angela Dispenzieri Ramsey Wehbe Panithaya Chareonthaitawee MD Grace Lin, MD, MBA Mayo Clinic CV Mayo Amyloid Ahmad Masri James Fang

summary slide of evidence for mechanical circulatory support. RCTs limited to 201 patients so far with no mortality reduction.5 matched comparisons all showing more complications and 4 higher mortality!!! Susanna Price chief Mamas A. Mamas Sean van Diepen

Our paper 'Efficacy and Safety of an Extravascular Implantable Cardioverter–Defibrillator' is now online: nejm.org/doi/full/10.10… presented at #esccongress2022 by Dr. Ian Crozier @mayoclinccv Mayo Clinic

Get Episheet, a free #epidemiology spreadsheet package that handles various epidemiologic analyses, including power calculations, exact confidence limits, rate standardization, seasonal analysis, P-value functions, meta-analysis, and more:
rtihs.org/episheet

Interesting new paper from DAPACKD on acute GFR declines in JASN_News

jasn.asnjournals.org/content/early/…

This is the early creat bump when you start a Flozin

Of course flozins cause more GFR declines than placebo:

#ResearchLetter : Longitudinal Evolution of Cardiac Dysfunction in Heart Failure with Normal Natriuretic Peptide Levels @michelenahecto Frederik H. Verbrugge Echocardiography Laboratory at Gunma University @Massaromard@bborlaugmd #AHAJournals ahajrnls.org/3Pn19OX

if you have new trainees (psych, cog sci, neurosci) and they are looking for resources to fill in gaps in statistics and R knowledge, point them to Danielle Navarro's page. It's hard to overstate what an incredible resource her work is learningstatisticswithr.com #rstats

Congrats to X. Jaïs and all the French PH network for this outstanding study (RACE study: phase 3 RCT on BPA vs Riociguat in CTEPH) published in Lancet Respiratory Medicine. Proud to be part of it.

thelancet.com/journals/lanre…

Muthu Vaduganathan John Mandrola, MD In🏨 initiation of GDMT in HFrEF demonstrated safe, well tolerated, rapidly effective with improved use/adherence

✅ ARNI: PIONEER-HF, GWTG-HF
✅ BB: IMPACT-HF, OPTIMIZE-HF
✅ MRA: EPHESUS, ATHENA-HF
✅ SGLT2i: EMPULSE, SOLOIST-WHF

🏨HFrEF patients at ⬆️⬆️⬆️ risk re🏨 and ☠️

What happens to GDMT use/dose from time of 🏨 discharge thorough 12 months f/u?

Nothing!!!

Inertia and omissions dominate in outpt settings

🎯In🏨 optimization GDMT and new strategies

ja.ma/3PIFCRx via JAMA

Grateful to Steve Greene for an amazing conference on hospitalized HF

Some Pearls🧠
1️⃣ Don’t consider GMDT..PRESCRIBE it
2️⃣ Treat HF with rapid sequence initiation of GDMT
3️⃣ A slice of 🍕 was not the trigger for the HF hospitalization, lack of GDMT initiation was!🤯

SUGAR-DM-HF: #empagliflozin reduced #kidney perfusion measured by #ASL , with directionally concordant changes in MRR, & reduced aECV in pts with #HFrEF & #T2DM or #Prediabetes . doi.org/10.1161/CIRCUL… University of Glasgow Heart Failure Research Group Metabolic Medicine Led by Paddy Mark Naveed Sattar Mark Petrie

Initiation of empagliflozin in patients hospitalised for acute heart failure

Improved symptoms, physical limitations & quality of life,

Benefits seen within 15 days

Study by Mikhail Kosiborod et al

ahajournals.org/doi/10.1161/CI…

Article 1️⃣: Put our ❤️ & soul into the Health Disparities AHA Research AHA Science AMFDP funded #FAITH ! @faith4heart Trial of a #HeartHealth #mHealth 📲🤳🏾 #lifestyle intervention among #AfricanAmerican #Churches 💒 Our app rocked 🎸

Please Read & CITE our results ▶️ ahajournals.org/doi/10.1161/CI…

We need an RCT. It’s time!

🔥 🔥 🔥

Impella vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock | Acute Coronary Syndromes | JAMA Internal Medicine | JAMA Network jamanetwork.com/journals/jamai…

Thanks for terrific collaboration Ryan J Tedford MD Kavita Sharma Frederik H. Verbrugge and rest of the team to objectively study approaches for diagnosis of HFpEF. Even more important now that we have effective treatments -SGLT2i.
jamanetwork.com/journals/jamac…