Timely collation, linkage and analysis of data has been key to informing the public health and clinical response in outbreaks of MERS, COVID-19, and Childhood Acute Severe Hepatitis of Unknown Origin ISARIC4C ISARIC #DataSavesLives

#DataSavesLives

I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research gov.uk/government/spe…

The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.

In general, the impact of Covid-19 on causing critical illness, i.e needing intensive care, in children lessened over the first two years of the pandemic, including when the omicron variant became dominant ISARIC4C ISARIC

Isabella Eckerle Eddie Holmes Yes, along with loss of biodiversity, changing habitats of animals, illegal wild life trade, urbanisation, trade and travel. All key drivers more frequent & complex epidemics & pandemics. The epidemic events are symptoms of our changing world & need to address the key drivers

TL;DR:

Our preprint was 1ST to report association btwn #AAV2 & hepatitis cases, found on metagenomic sequencing in 9/9 early 🏴󠁧󠁢󠁳󠁣󠁴󠁿cases vs 0/58 controls. #adenovirus found in 6/9 cases.

Cases also >likely to carry HLA DRB1*04:01 allele (8/9; 89%) vs 🏴󠁧󠁢󠁳󠁣󠁴󠁿blood donors (16%) 2/

Doctors, scientists, & public health teams are working together, learning lessons from their responses to past outbreaks pandemics. This new way of working has led to the rapid discovery of the cause of this mystery disease ISARIC Kenneth Baillie Professor Calum Semple OBE

U.S. FDA Advisory Committee (VRBPAC) voted support the safety and effectiveness of GSK AREXVY™  (RSVPreF3 OA), 12-0 on effectiveness and 10-2 on safety.

precisionvaccinations.com/rsv-vaccine-vo…

Cases (n=9):
- admitted 14 March-4 April 22
- recruited to ISARIC4C
- 4 male; median age 3.9 (IQR 3.4-5.1)
- most had GI symptoms 1-11 wks b4 hepatitis
- no immunocompromise
- none had covid 💉
- Hep A-E, EBV/CMV, HHV6/7, HSV, autoantibodies neg
- no transplants/ deaths

2/

ISARIC ISARIC4C publication on our data platform. Thank you all partners & members for your contributions.

rdcu.be/cSWBU

Comment piece from David Ulaeto, Miles Carroll & me: Evolutionary implications of human transmission of monkeypox: the importance of sequencing multiple lesions thelancet.com/journals/lanmi…
We need multiple lesion samples & sequencing now to prove this ISARIC ISARIC4C

Timely release of our latest ISARIC4C study, led by Lance Turtle, evaluating impact of #immunocompromise (IC) on outcome in hospitalised #COVID19 .

TL;DR: Despite effective 💉& Rx, IC individuals remain at ⬆️ risk of death from COVID19 compared to immunoconpetent persons.

🚨New preprint🚨

Adeno-associated virus 2 infection in children with non A-E #Hepatitis

A case-control investigation of 9 early cases in #Scotland & 58 controls.

MRC-Uni of Glasgow Centre for Virus Research Public Health Scotland Royal Hospital for Children, Glasgow ISARIC4C UCL UK Health Security Agency Emma Thomson

🧵1/
medrxiv.org/content/10.110…

Great result and further evidence of the value of preparedness studies set up in readiness for future outbreaks of novel disease Gail Carson (the original CI), Professor Calum Semple OBE (CI & coLead) Kenneth Baillie (coLead), Peter Openshaw (coLead), Jake Dunning & many more

Brilliant News Jo and Team. Thank you so much for your help with ISARIC4C ISARIC

Many many congratulations to Shona Moore, winning the Outstanding Contribution During The Covid-19 Pandemic, Shona and the team in our outbreak laboratories delivered the ISARIC4C which saved lives and enabled discovery on #COVID19

For UK hospitals that are ISARIC4C sites or are treating monkeypox patients and want to offer participation in the UK version of the CCP, see the updated UK CRF at isaric4c.net/protocols/
ISARIC4C

For UK hospitals that are ISARIC4C sites or are treating monkeypox patients and want to offer participation in the UK version of the CCP, see the updated UK CRF at isaric4c.net/protocols/ ISARIC4C

From ISARIC4C

From ISARIC4C Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages | mSphere journals.asm.org/doi/10.1128/ms…