Cancer Discovery News #NotedThisWeek : A curated list of recent breaking news.
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Thank you Cancer Discovery for this amazing artwork. Seattle Children's, Seattle Children's Therapeutics (SCTx), and the #VitanzaLab are honored to share this research with your AACR audience & beyond. Looking at this, I see the face of every kid we've enrolled. We will keep doing everything we can to #EndDIPG

An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal #Lymphoma , by Venturutti Lab, Melnick Lab et al.
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BC Cancer Weill Cornell Medicine #BCCRC

Read this week's Cancer Discovery #ResearchWatch :
CRISPR-CATCH Improves Human ecDNA Profiling in Tumor Tissue, summarizing the work of King L Hung, Howard Chang et al.
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Stanford University HHMI NEWS

#NewsinBrief : Testing Proton FLASH RT in Bone Mets.
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Read this week's Cancer Discovery #ResearchWatch :
19F MRI Enables Monitoring of Tumor-Associated Macrophages in Cancer, a summary of the paper by Davide Croci, Johanna Joyce et al.
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Johanna Joyce Lab Université de Lausanne Ludwig Cancer

This is so exciting. Thanks to Cancer Discovery Margaret Foti, PhD, MD (hc) for the opportunity to share our story.

😍😍😍 Congrats!! So happy to see these two amazing BTB Cancer Discovery papers from some of my favorite people - congrats to everyone involved!

#senescence #cancer #tumorimmunology #HappyFriday

Our work on how molecular mechanism of MMR deficiency affects immunotherapy outcomes is out on Cancer Discovery! Check out the thread by the amazing Ryan Chow. Many thanks to Dr. Santin, Prof. Akiko Iwasaki for letting us take the lead on this project and to the coauthors!

I am just amazed that Dr. Prof. Akiko Iwasaki has a Science Magazine paper on inducing mucosal immunity using intranasal vaccines (“prime and spike”) AND a paper in Cancer Discovery on molecular mechanisms of response to #immunotherapy in MSI+ endometrial cancer ON THE SAME DAY
🤯🙏🏽

New in Cancer Discovery, JAX's Jennifer Trowbridge shows that aging-induced TNFα signaling promotes selective advantage of mutant HSCs and proposes cell surface receptor TNFR1 as a target to reduce clonal hematopoiesis and risk of associated diseases:

jax.org/news-and-insig…

Check out the Cancer Discovery papers highlighted in the latest AACR Journals collection on #COVID19 and Cancer. bit.ly/3zKo2XJ

Osimertinib + Savolitinib to Overcome Acquired MET-Mediated Resistance in EGFR-Mutated MET-Amplified Non-Small Cell #LungCancer : TATTON, by Ryan Hartmaier et al.
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From the October issue: Impaired Proteolysis of Non-Canonical RAS Proteins Drives Clonal Hematopoietic Transformation, by Sisi Chen, Rahul Vedula, Antonio Cuevas Navarro, Pau Castel, Abdel-Wahab Lab et al.
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Memorial Sloan Kettering Cancer Center Dana-Farber UCSF Helen Diller Family Comprehensive Cancer Ctr NYU Langone Health

Published today in Cancer Discovery: Yale Cancer Center researchers discover for the first time ever, differences in response for #endometrial #cancer treated with #pembrolizumab bit.ly/3f955Xx. #gynsm Smilow Cancer Hospital Yale School of Medicine Yale New Haven Hosp

Mismatch repair-deficient (MMRd) cancers all have ⬆️high mutation burdens, so why do some patients not respond to immune checkpoint blockade (ICB)? We explored this in a follow-up to a phase 2 trial of aPD-1 (pembro) in MMRd endometrial cancer Cancer Discovery : aacrjournals.org/cancerdiscover…

This was a great collaboration with the labs of Alessandro Santin, eric hoyeon song, Prof. Akiko Iwasaki Yale School of Medicine Yale Cancer Center. Shout-out to🌟undergrad & co-1st author Tai Michaels! Thanks to all co-authors, I-Mei Su Cancer Discovery & reviewers, and the patients for participating.

Register by October 28 to get the lowest rates for the 12th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Translating Knowledge into Practice (December 10-14, Maui, Hawaii). Learn more:
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