Exchangeable leaders of collectively migrating #glioma abuse N-cadherin trafficking. Takeshi Kawauchi and Shiho Ito Kyoto University discuss recent work from Dayoung Kim et al. (hubs.la/Q02w1r430) in Spotlight: hubs.la/Q02w1pZ80

#Septins restrict the intracellular motility of GFP-CD63 #endosomes and promote their maturation from EEA1- to LBPA-positive multivesicular bodies/late endosomes. From a study by Robinson et al. Elias Spiliotis Drexel University College of Arts and Sciences UVa Cell Biology: hubs.la/Q02v9nrS0
#cytoskeleton

Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase - Gabriella Darmasaputra Cindy Geerlings matilde galli et al Hubrecht Institute use fetal-derived hepatocyte organoids to investigate the regulation of endomitosis in vitro hubs.la/Q02wPPkc0

CAD cells in early stages of differentiation. See more in our recent JCellBiol paper where we used them to reveal what prolonged depletion of PFN1 or actomyosin did to microtubules in neuron-like processes (hippocampal neurons too!) #FluorescenceFriday hubs.la/Q02wGZ5s0

.Dan Tudorica, Hurley Lab et al. Aligning Science Across Parkinson’s find that RAB7A phosphorylation in PINK1/Parkin #mitophagy displaces the #autophagy inhibitor Rubicon, whilst recruiting the structurally related positive regulator Pacer. hubs.la/Q02wPH680

Bishal Basak Erika Holzbaur-Howland

.Megan K Chong, @RosasSalvan, Vanna Tran and Sophie Dumont UC San Francisco show that chromosomes biorient and correct errors with varying efficiencies. Chromosome size and the spindle forces that scale with size determine error correction efficiency. hubs.la/Q02wPxKy0

#CellDivision

Did we have to go against everything I believe in and study microtubules- YES. But I couldn't be more proud of the team and this paper which adds a new wrinkle to the story about profilin and microtubules and details the repercussions of prolonged loss of profilin or actomyosin.

In this Viewpoint, Campanella and Kannan Queen Mary University of London discuss the contacts between #mitochondria and nucleus in mammalian cells, yeast, #Plasmodium falciparum, and #Toxoplasma gondii, highlighting recent work by @sheinerlab (hubs.la/Q02wNNZc0): hubs.la/Q02wNL-R0

Attending the FASEB FASEB Biology of Cilia and Flagella 2024 #BCFSRC in St. Paul? If you're interested in submitting your research to JCB, get in touch with our Scientific Editor Dan Simon who is attending! Contact Dan via email ➡️ hubs.la/Q02wNMzz0

Cell growth is required for #cellcycle progression, but the molecular mechanisms that enforce this critical dependency are unknown. New work from Talavera, Kellogg et al. UC Santa Cruz suggests that the Mitotic Exit Network (MEN) links mitotic exit to cell growth. hubs.la/Q02wJh_g0

Yuka Kamada, Tsukasa Okiyoneda et al. 関西学院大学 report that the cytosolic E3 ligase HERC3 provides a branch of the ERAD pathway for membrane proteins by recognizing the transmembrane domain. hubs.la/Q02wH1Pc0

#Biochemistry #ProteinHomeostasis

.Bruno, Eric Vitriol MCG et al discover that #microtubule number & stability increase following prolonged depletion of profilin 1 or F- #actin due to loss of actomyosin contractility. It is reversible if actomyosin is restored. hubs.la/Q02wGZ5s0
#cytoskeleton

Happy to see our STED image on the cover page of JCB !!

Microglial TNFα controls daily changes in synaptic GABAᴀRs and sleep slow waves, say Maria Joana Pinto, Clément Léna, Véronique Fabre, Alain Bessis and colleagues IBENS École normale supérieure | PSL: hubs.la/Q02vSY2S0

#CellSignaling #Neuroscience #microglia

Schematic shows dual regulation of #proteasome and #autophagy –lysosomal pathway by Nrf1. Ward, Vangala, Kamber Kaya, Radhakrishnan and colleagues VCU expand the role of Nrf1 in shaping the cellular response to proteotoxic stress. hubs.la/Q02tZ3_k0

Spotlight: Friedl and Zegers Radboudumc discuss new work by Yoon, Adam Marcus PhD et al. (hubs.la/Q02wxPgH0) that finds paracrine signaling from collectively invading #cancer cells induces dissemination of single cells in the same population. hubs.la/Q02wxRXW0

Wen, Paull et al. Molecular Biosciences show that loss of the RNA/DNA helicase Senataxin in human cells results in aggregation of cellular proteins and proteotoxic stress. hubs.la/Q02wxw_M0
#DNABiology #ProteinHomeostasis

Xiaorong Pan, Yiqing Hu, Tong Iris Wang et al. find that actomyosin-II–driven reversible beading underpins the resilience of central axons to mild mechanical stress by suppressing the propagation and firing of injurious Ca²⁺ waves. hubs.la/Q02wy0SJ0
#Neuroscience #TBI

Our 'Axon Beading Story' is online today. Many thanks to our collaborators and reviewers. It's been a great experience to complete it. Fred Meunier Prof. Chun-Xia Zhao JCellBiol
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Actomyosin-II protects axons from degeneration induced by mild mechanical stress rupress.org/jcb/article-ab…

A role for a dynamic #BasementMembrane during development and disease is underexplored. Tools are now there to dissect BM component dynamics in several model systems. Have a look! Thanks Dave Sherwood for the fun discussion.