Wondering how microRNAs can have mighty impacts on the transcriptome?
Here (rdcu.be/dHdub) we show how miR-144 effects expand beyond its direct targets by targeting a chromatin regulator during hematopoiesis. Congratulations, team!

It 🤯 every time I watch it
PS: Charlton Heston playing a Mexican is also… “unique”

GutkindLab and I are looking forward to seeing you all at the 2025 GRC in Molecular Pharmacology. Please apply for short talks. We are interested in applications from historically marginalized groups, e.g., Black Women in STEM, 500QueerScientists, @DisabledSTEM grc.org/molecular-phar…

GLP-1 analogues that induce prolonged signaling relative to GLP-1 Patrick M Sexton biorxiv.org/content/10.110…

Definition of a classic. The translation to Spanish of several editions was done in the Dept where I did my PhD, with contributions from my mentor Aida Marino, and later I discovered that my postdoc mentor Marilyn Farquhar and her husband were friends of the Stryers. Small world

RIP Lubert Stryer - his Biochemistry was my first college textbook, a gift from the lab where I had a summer job

New publication from the group:

'Mechanistic insights into G-protein activation via phosphorylation mediated non-canonical pathway'

sciencedirect.com/science/articl…

#Gprotein #GPCR #MDSimulation

Congratulations Kunal Shewani

Network at the only meeting specifically dedicated to mammalian synthetic biology and its applications. Immerse yourself in the field's latest developments and connect with dynamic researchers. Learn more and register at bit.ly/49qbofF

#SBE #mSBW2024 #research

Excited to share our paper on the role of RGS4 on ketamine actions, by the brilliant Vicky Mitsi. Vicky is a force in the lab and in basketball courts. A collaboration with Li Shen, Eric F. Schmidt Lab , Eric J. Nestler, MD, PhD and  a great team ihttp:molpharm.aspetjournals.org/cgi/reprint/10…

The perfect genomics method name doesn't exi...

Very happy to have my recent work on 'Time-resolved cryo-EM of G protein activation by a GPCR' out in Nature today! #cryoEM #GPCR nature #LabSkiniotis nature.com/articles/s4158…

Drug discovery is hard

This review is on the curious case of when G proteins are not activated by a #GPCR . This is close to my heart and it has been ~15 years since I got a first glimpse of a new mechanism for it. I also tried to cover what tools can be use by YOU to work on it! doi.org/10.1016/j.jbc.…

This is also my pick. The scene of the clip is amazing at many levels.

Composers are uber-musicians

Here you have a clip of Salieri’s revenge:
youtu.be/S0S4pL3_1-U?si…

This is objectively meaner than anything Scorsese has said

Exciting news! Our department invites applications for Assistant Professor Positions
#pain #somatosensation #Substanceusedisorders
#CAMed
AcedemicJobsPosition ID:Boston University Chobanian & Avedisian School of Medicine-Pharmacology-Physiology & Biophysics-AP1 [#27116]

Very nice review. Highly recommend it.

Question for Andreas Bock and Roshanak Irannejad now that John is not listening, does he swear a lot also while writing? I envy you…