I did it! 🚀

🚨Centre for Genomic Regulation (CRG) is a great place to work. The Genome Biology Program is excellent. 😃 Join us! 👇🏻

recruitment.crg.eu/content/jobs/p…

Friends, please, retweet 🔄

Curious about a showdown between 10x Genomics' Xenium & NanoString's CosMx platforms ran in my lab and on sequential sections?

Join us on Oct 25 at 4:30 pm AEDT #ozsinglecell23 !

#SingleCellSpatial
#MetricsMatter
#DataSpeaksTheTruth
#More2Come
#CutAboveTheRest

Our new work asks which genomic elements are capable of setting up cell type-specific regulatory domains? Using analysis of natural variation combined with synthetic biology we show enhancers are both necessary and sufficient for their formation. biorxiv.org/content/10.110…

Finally we can share in full our long journey from mouse & human embryo implantation 10 years ago, through many mouse models, to this human embryo model. A decade long but a beautiful & fulfilling journey with wonderful people, too many to mention all here nature.com/articles/s4158…

Check out our latest preprint:
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development biorxiv.org/content/10.110…

I’m fine getting rid of Environment, which was useless. But are they really saying that PI productivity is no longer a factor? To me, this should maybe be the biggest factor? One person has 10 good papers, another 2. But they both just get same pass?

nexus.od.nih.gov/all/2023/10/19…

Excited that our paper addressing the limited overlap between eQTLs and GWAS hits is now published in Nature Genetics! nature.com/articles/s4158…

New preprint! We studied how single-cell 3D chromatin structure changes under targeted epigenetic perturbations using multiplexed DNA FISH and synthetic biology tools, and found an intriguing relationship between chromatin compaction and epigenetic memory. biorxiv.org/content/10.110…

...And the manuscript is now out in Nature Communications: nature.com/articles/s4146…. Here a long-due but (hopefully) short thread:

Human effector CD8+ T cells with an exhausted-like phenotype control tumor growth in vivo biorxiv.org/cgi/content/sh… #biorxiv_immuno

Thrilled to share our new joint research with Nuo Li’s lab! Dive into our deep exploration of the cortico-cerebellar connectome. We pinpointed cerebellar 'hotspots' that uniquely connect to the frontal cortex, form an intricate cortico-cerebellar channel for motor planning.

Out now in nature! Ultra-fast deep-learned CNS tumour classification during surgery using Oxford Nanopore sequencing. Great teamwork by my team UMCU_CMM and @Oncode (@CarloVermeulen4 and Marc Pagès), the PrinsesMáximaCentrum (Bas Tops) and Amsterdam UMC nature.com/articles/s4158…

Excited to share our paper on the first small molecule inhibitors of PTPN2/PTPN1 for cancer immunotherapy out today in nature nature.com/articles/s4158…

This has been a collaboration with Calico and AbbVie. Very proud of the amazing team that made this happen! Explainer below👇

We are looking for a motivated PhD student to join the Jurgen Marteijn at the Erasmus MC to study transcription-coupled DNA repair using single-molecule imaging technologies. Apply via bit.ly/3tjZwME

Do not miss this outstanding opportunity and join IMMERGE
to fight against #PrimaryImmunodeficiencies

We are recruiting 12 PhD candidates!!

Apply here: …-josep-carreras-ijc.jobs.personio.com/job/1223773?la…

BREAKING NEWS
The 2023 #NobelPrize in Chemistry has been awarded to Walter White for promoting an understanding of synthetic organic chemistry to the general public. This unprecedented selection is bound to spark controversy, but Walter is/was an undeniably inspiring figure...

We're proud to present our latest Cancer Discovery study, in collaboration with Neta Erez- ErezLab, unraveling the intricacies of immune cells in breast cancer metastasis & revealing that TREM2 macrophages regulate the invasive margins of metastases. >>> doi.org/10.1158/2159-8… (1/12)

Proud to share our #eGTEx multi-tissue dissection of #enhancer H3K27ac across 387 brain, muscle, heart, and lung samples from #GTEx in Nature Genetics
#eQTLs #haQTLs #SexDiffs #Epigenomics #GWAS #linking
Paper: nature.com/articles/s4158… (H3K27ac, today)
News: csail.mit.edu/news/unlocking……

Bloemen van studenten, patiënten, collega’s en anderen stromen binnen. Om stil te staan bij de heftige gebeurtenissen van gisteren is een officiële gedenkplek ingericht bij de hoofdingang van het Gk-gebouw, Rochussenstraat. Iedereen die dat wil kan hier bloemen achterlaten.