We have two new faculty/group leader positions available at Bristol Biochemistry at Lecturer/Senior lecturer /Associate Professor levels. Links below. One with a broadly defined 'omics' remit and the other anything Biochemistry, Biophysics, Molecular Cell Biology or Syn Bio. Join us!

Please help us spread the word:
We are looking for 2 group leaders IMBA, a basic research institute at the Vienna BioCenter.
I started a lab at IMBA 14 years ago and it has been an incredibly rewarding experience. The dynamic and collaborative research community ...

This is a great opportunity - excellent mentor and excellent science 👇

1/ A new paper from PhD student Marius Hedtfeld tests in vitro phase separation assays as predictors of localisation in cell compartments.

authors.elsevier.com/sd/article/S10…

We explain why homotypic or simple heterotypic LLPS assay are unlikely to predict macromolecular localization...

Excited to share our new study on an unusual dynein cargo: an intracellular bacterium! We show that Orientia tsutsugamushi hijacks dynein via BICD2 adaptors. Led by Giulia Manigrasso with Jeanne Salje's group. Out now in bioRxiv! A thread 🧵 (1/6)
biorxiv.org/content/10.110…

New preprint alert!
We describe a new way to detect membrane curvature preference for proteins. The big advantage of our method is that it uses an out-of-the-box equipment (Nanosight Malvern Panalytical), with no modifications. 1/14

biorxiv.org/content/10.110…

Do you like to look after specialist lab equipment, train users, teach students practical lab skills and support them in their first research projects? Then join us as a research support specialist. This is a rare permanent role BioMedSci Warwick. More info:
jobs.ac.uk/job/DGT760/res…

REMINDER, PLEASE RETWEET AND SHARE!!!!

Less than 2 weeks left to register and be considered for a short talk!

This is a one of a kind program including talks from various cytoskeletal experts. You DO NOT want to miss out on this GRC (or for trainees to miss out on the GRS!)

Extremely happy to share the first manuscript of the lab! 🥳🥳🥳In this paper, we have looked at the coupling between delamination and differentiation at gastrulation. If you are interested in pluripotency, gastrulation, and mouse embryos keep reading! sciencedirect.com/science/articl…

Our work on how the lysosomal adaptor JIP3, and regulator LIS1 activate the dynein motor protein is now out in Science Magazine ! science.org/doi/10.1126/sc…
Many thanks to our reviewers and editor for their valuable input.

Our new paper is out in @Development. journals.biologists.com/dev/article/15…
@StJohnstonlab Gurdon Institute Andreas Prokop

events.faseb.org/xPaPRG?sms=2&c…
Don't forget to register for the best meeting this summer!

Join us in Coimbra MIA Portugal Universidade de Coimbra in May. The #Ageing School is a great opportunity for #ECRs to present their research, brainstorm and network in an informal setting and very lovely surroundings!
Free registration (what?!) and many slots for elevated talks!

Exciting opportunity to join Greg Jefferis group in the LMB’s Neurobiology Division, working on a collaborative project with AstraZenecaUK to investigate gene programmes driving neuronal diversity & wiring specificity.

nature.com/naturecareers/…
Deadline: 03 APR
#ScienceJobs

Microtubules play diverse cellular roles, including in the mitotic spindle. They are also key targets of anti-mitotic chemotherapies. Using large-scale functional genetics, our latest works reveals enhancers + suppressors of microtubule drug sensitivity.
biorxiv.org/content/10.110…

Simon Bullock (Simon Bullock) and research team together with AstraZeneca report in JCellBiol the results of a genome-wide arrayed CRISPR screen for novel players in dynein-based cargo trafficking.

Read more: www2.mrc-lmb.cam.ac.uk/a-genome-wide-…
#LMBresearch

Wu, Hammarlund et al. Yale School of Medicine show that the endogenous #kinesin -1 and RIC-7 localize at the leading end of #mitochondria to drive axonal anterograde transport in vivo in #Celegans . hubs.la/Q02p60gv0

#Neuroscience #Organelles #Trafficking

Very happy our kidney organoid paper on MET/epithelial polarisation in nephrogenesis is now out in print at Developmental Cell, and we have the cover picture! Great work by JP Ng-Blichfeldt, Clatworthy Lab, Benjamin Stewart, AstraZeneca, done MRC-LMB Cell Biology MRC Laboratory of Molecular Biology cell.com/developmental-…

New paper from the lab: Regulation of #TLR4 #trafficking by the #ERAD intramembrane protease RHBDL4. A mechanism that prevents an excessive innate #immune response. Congratulations to Julia Knopf, Susanne Steigleder and all authors! nature.com/articles/s4146…

How the #dynein motor orchestrates cargo transport in cells is unclear. Wong et al MRC-LMB Cell Biology AstraZeneca present an arrayed genome-wide #CRISPR screen that identifies many novel players in dynein biology, as well as several other cellular processes hubs.la/Q02nnvp-0