Dear baby bioinformaticians, if a potential wet-lab collaborator says bioinformaticians are 'a dime a dozen', run as fast as you can in the opposite direction.

[on Hinge date]

me: so you’re paying right

her: ummm why do you think that

me: I work in AI safety

her: oh ok why didn’t you just say so. your marginal dollar is better spent on improving your productivity rather than on this date. no worries at all I’ll gladly cover the bill

on all cocktail menus there should be an asterisk next to any drink that the bartender is going to be annoyed with having to make

Over 12,000 hits for height have been discovered in a new GWAS!
(Yengo et al., nature.com/articles/s4158…)

How many more are there to be discovered?

Thread. 🧵

The single easiest thing you can do that will spark with joy is to block all emails from Frontiers. What a horrific dumpster fire of a publisher.

AllofUsResearch Tim Frayling I did, this morning, and this is what I saw. At what stage does this start to undermine US/NIH leadership on global data sharing?

Our lab's latest protocol, more brilliant work from Beth Martin 🌹 & Chengxiang Qiu

We can't send to bioRxiv b/c they desk-reject all protocols ;) Onwards to eLife - the journal where I predict Michael Eisen #FF7518's assessment will be 'delicious'

Non-paywalled PDF: tinyurl.com/3zsyabpp

There's actually a serious point here. Children tend to have milder infections.
So when I see people say that the older are at greater risk of reinfection (because their protection wanes more), that's kind of the ... opposite ... to what the data says on how these risks go.

ONS has some data-driven advice this morning for those trying to engineer natural infection as their defence vs future COVID infection.
Please manage your illness to give your first infection a Ct value of 27. Too mild, or too serious an initial infection are both less effective.

I'm also extremely interested in this question. OKRs are an appealing framework for mapping organisational goals down to individual goals, but it's not clear to me how you'd apply them to the necessarily uncertain plans in research orgs. Would love to hear thoughts on this!

I am looking for examples of OKRs at research orgs.

A FRO team member told me that the classic engineering or customer success examples aren't useful. Looking for something from scientific research - capturing/allowing for the uncertainty in research projects.

🤯 The black death killed 30-60% of Europe so it's reasonable to think it affected the allele frequency spectrum.

Absolutely incredible nature paper using ancient DNA pre-post the black death to show positive selection of immune genes due to the plague (Fig2d-g).

Massive news: eLife to abolish accept/reject decisions: papers will just be “peer reviewed”. Others can argue about this, but lots of interesting consequences. 1/9 elifesciences.org/articles/83889

'Human Evolution' generated by Artificial Intelligence.

In Next-Generation sequencing news, we have been digesting the Chemistry X and $200/genome announcement by $ILMN Illumina for a few weeks now, and next in line are $PACB PacBio, MGI Tech and $ONT.L Oxford Oxford Nanopore to give updates between now and the year end.

Our work on natural selection during the Black Death is now published!!

We present evidence of genetic adaptation at immune loci, functionally characterize adaptive loci, and reveal connections between selection during the BD and modern health. 🧵

nature.com/articles/s4158…

Ioannides failed to do a basic check of plausibility in his recent study of seroepidemiology and IFR for COVID. He estimates IFR for 0-18 yo's at .0003%. If true, the 1661 COVID deaths for 0-18 in the US would require 554 million infections (1661/.00003). covid.dropcite.com/articles/7b8ba…

If Trump was still in office and our government was trying to claim #COVID cases are 'low' because rapid home tests aren't being counted, and ending mask recommendations in hospitals and not wearing masks in children's hospitals, it seems like a lot more of you would be angry.

Want to know the impact of incidental findings of a pathogenic mutation in common MODY genes?

👇👇👇

sciencedirect.com/science/articl…

Implication for incidental findings for common MODY genes. great collaboration with Geisinger.