TCR engagement inhibits IL-7R signalling by reducing JAK1 transcription and by inducing miR-17 which inhibits JAK1 translation Katz et al – Science Signaling 2014 science.org/doi/10.1126/sc…

Today in Nature Biotechnology, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬 nature.com/articles/s4158…

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases go.nature.com/3zPEIjp

I'm a little late to the party, but glad to share that our manuscript describing click editing has been published in Nature Biotechnology. An amazing team effort led by Joana Ferreira da Silva Connor Tou & others. CGM at MGH Mass General Research Institute Harvard Medical School #clickediting 🧬 nature.com/articles/s4158…

Cosmc is a chaperone required for extended O-glycans. B-cell conditional Cosmc-KO leads to a maturation and migration defect of B cells in mice. On component is that O-glycosylation of CCR7 and CXCR4 seems to be necessary for chemokine responsiveness 1/2

To new adventures! Leaving Berlin for a bit and excited to move to Boston to join the lab of Deepak Rao Harvard Medical School Brigham and Women's Hospital as a Marie Sklodowska Curie Fellow in October. Also, if you can link me to some affordable housing near BWH, that would be great 😅

What is the differential function of the many inhibitory receptors on T cells? While PD-1 KO T cells have improved proliferation and persistence (and express even higher TOX), LAG-3 KO become more functional (cytotoxicity, cytokines), but struggle to persist. 1/2

Having a hard time with #CRISPR HDR? Your cells might be fighting against you! TREX1 nuclease, high in some cells, eats up HDR donor templates. Check out our paper in Nature Biotechnology for the story & ways to improve HDR. nature.com/articles/s4158… With Erman KARASU & John Maciejowski

T cells express a ton of CD5, so why CD5 CAR T cells don't kill each other? Turns out, they completely degrade CD5 protein and thus evade fratricide. Unique mechanism unveiled in a mechanistic study - and PhD thesis work - by Royce Ma: cell.com/cell-reports-m…

How do glucocorticoids work in myeloid cells? Inflammation induces Acod1 (which generates antiinflammatory itaconate) – however, only when glucocorticoids release the glucocorticoid-R from the pyruvate dehydrogenase and thus the TCA cycle, Acod1 receives substrates to work. 1/2

1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in Nature Cell Biology! nature.com/articles/s4155…. 🧵 below:

Baylor College of Medicine receives more than $17 million from CPRIT #CancerResearch Dan L Duncan Comprehensive Cancer Center Center for Cell and Gene Therapy blogs.bcm.edu/2024/08/22/fro… via BCMHouston

Thank you Adrian Gee for 25 years at CAGT and enjoy all the travel planned in your retirement! 🧳 🗺️ Thank you also to Tonie Tran for the spectacular cake 🎂

Delighted to share our latest work NDT that brings us one step closer to understanding B cell activation in IgA nephropathy 🧐 Recent GC emigrant DN1 B cells are the precursors of galactose-deficient IgA-secreting cells 🤯 1/2 Link to article: doi.org/10.1093/ndt/gf…

Was fun to tune in online with a mini watch party yesterday to catch Joana Ferreira da Silva's presentation on updated & engineered #clickeditors at the Cold Spring Harbor Laboratory #CRISPR talk (on behalf of a large collaborative effort in the lab). Excellent talk, Jo! 🧬👏 CGM at MGH Mass General Research Institute MassGeneral News

Excellent results with autologous CD7-PEBL CART in T-ALL from Singapore and Rome nature.com/articles/s4159…

Safeguarding the integrity of regulatory T cell products requires depleting the effector memory–like subset Science Advances science.org/doi/10.1126/sc…

T cell engagers for autoimmune disease 💥 Happy to share our latest study demonstrating the feasibility of the CD3xBCMA T cell engager Teclistamab in patients with refractory Systemic sclerosis, Sjogren‘s syndrome, Dermatomyositis and Rheumatoid arthritis. nejm.org/doi/full/10.10…

This study shows that using early memory T reg cells and removing effector memory cells improves the stability of Treg therapies.👇 By Leila Amini, Sarah Schulenberg, Lena Peter, Tino Vollmer, Weijie Du, Timo Rückert, Dimitrios L. Wagner, et al. from BIH Center for Regenerative Therapies science.org/doi/10.1126/sc…