Thinner is not always better: Optimising cryo lamellae for subtomogram averaging biorxiv.org/cgi/content/sh… #bioRxiv

10th anniversary edition of the CCP-EM Spring Symposium is open for registration! Includes the DLS BCI user meeting from our friends Diamond Light Source . For more info... ccpem.ac.uk/training/sprin…

The final version of the PyTME paper published in SoftwareX Journal! PyTME enables fast CPU and GPU-based template matching in #cryoET and fitting in #cryoEM. More in the thread with plenty of screenshots👇 sciencedirect.com/science/articl…

Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution biorxiv.org/cgi/content/sh… #biorxiv_biophys

Join our lab as RA! We will provide an exciting environment for you to grow as a scientist. Min. 1 year, up to 3 years!

Very happy that the #ModelAngelo paper is out today in nature ! This was a super fun collaboration with Lukas Käll Rui Zhang Alan Brown Dari Kimanius Sjors Scheres nature.com/articles/s4158…

Simon Bullock (Simon Bullock) and research team together with AstraZeneca report in JCellBiol the results of a genome-wide arrayed CRISPR screen for novel players in dynein-based cargo trafficking. Read more: www2.mrc-lmb.cam.ac.uk/a-genome-wide-… #LMBresearch

Our work on the ultrastructural landscape of extracellular matrix is now published in JCellBiol. Congrats to the fantastic Bettina_Zens for this achievement, her heroic efforts made this project possible! Also thanks to all other authors ISTAustria. doi.org/10.1083/jcb.20…

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus Congrats Hannah Ochner Jan Böhning Abul Tarafder MRC Laboratory of Molecular Biology Ido Caspy 💔🎗 Zhexin (Eric) Wang biorxiv.org/cgi/content/sh…

AlphaFold3 is out! This a diffusion model pipeline that goes beyond what AlphaFold2 did: predicting the structures of protein-molecule complexes containing DNA, RNA, ions, etc. Blog post: blog.google/technology/ai/… Paper: nature.com/articles/s4158… A quick thread about the method↓

Modern #cryoEM: I need to store my data at 10000 bit and 0.1 Å per pixel!!!! Micrograph from 1974 shot on film, scanned, printed for submission, scanned by journal, printed, scanned from some archive >30 years later, heavily compressed, reprocessed by Bjorn Forsberg:

Membraneless channels sieve cations in ammonia oxidising marine archaea. In situ structure of an ammonium trapping S-layer from Andriko von Kügelgen. nature.com/articles/s4158…

PhD position available the Peijun Zhang Lab! This is a wonderful opportunity - feel free to drop me a message for more informal inquiries about PhD life in the lab! ndm.ox.ac.uk/study/dphil-th…

🎉 Announcement: Prof. Peijun Zhang Elected to EMBO Membership! 🎉 Thrilled to share that Peijun Zhang has been elected to the European Molecular Biology Organization (EMBO) membership. the Peijun Zhang Lab Congrats, Prof. Zhang! 🙌🏼🔬 #EMBO #StructuralBiology #ScienceCommunity

👀Check out the latest #cryoEM #helical reconstruction workflow in Bio-protocol using CryoSPARC of #bacterial appendages by Juan Sanchez and Joe Baumgardt! bio-protocol.org/en/bpdetail?id… Tips and tricks on working with straight and bending filaments! ❄️🔬🧫

Thrilled to share our exciting work on the Nipah virus polymerase complex! This is a significant step forward in understanding and combating this deadly virus. Stay tuned for more exciting updates! Structure of the Nipah virus polymerase complex researchsquare.com/article/rs-466…

CryoDRGN-ET❄️🐉 is published in Nature Methods! We combine neural fields and generative modeling to reveal the structural heterogeneity of protein complexes *in situ*! So excited to see this out, and huge congrats to Ramya Rangan, Ryan Feathers and team! nature.com/articles/s4159…

Over the moon about this work! 🤩 Sam @Samlacey combines cryo-EM, #teamtomo magic, #AlphaFold, and structural proteomics (with Andrea Graziadei) to reveal the molecular structure of retrograde IFT. Massive breakthrough by an incredible talented young scientist. Bravo Sam! 👍 🚂

Frizzled receptors are essential for all multicellular life, from hydra to humans. Please check out our new paper on how we used nanobodies to elucidate the structure and function of Frizzled 3: nature.com/articles/s4146…

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…