🔬 Scientists demonstrated the usefulness and necessity of a pooled design to reveal donor #iPSC line heterogeneity during #macrophage cell differentiation and to model rare WT1 🧬 mutation-driven kidney disease with chimeric #organoids .

Nature Communications | go.nature.com/4dGLx68

Researchers characterized 🧫 hepatocyte #organoid outgrowth!

🤰 Fetal #hepatocytes initiated reciprocal transcriptional programs involving increased proliferation and repressed lipid metabolism upon initiation of organoid growth.

📖 Nature Communications | go.nature.com/4bDoMOO

Scientists observed that CHIR induced apoptosis of #iPSCs during the initial stage of renal 🧫 #organoid differentiation.

Underlying mechanisms implied the accumulation of reactive oxygen species and 📉 decreased #autophagy .

📖 bit.ly/3JWgfdT

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📖 Download our NEW free e-book for protocols on isolating tissue and establishing organoid culture: bit.ly/44DJdJ5

🔎 Researchers at Osaka University attempted to culture human liver #organoids established from 🧊 cryopreserved primary human #hepatocytes , using HYDROX, a chemically defined 3D nanofiber.

Scientific Reports | 🔗 go.nature.com/3WGyls6

Researchers characterized stressor-specific changes in senescence phenotype, its related molecular patterns, and 🧫 cellular bioenergetics in primary 🐭 mouse #hepatocytes and hepatocyte-derived liver #organoids .

🔗 bit.ly/4agxG3F

Investigators showed that PSC-derived PTEN mutant human 🧠 #neurons , neural precursors, and 🧫 cortical #organoids recapitulated disease-relevant phenotypes, including hypertrophy and structural overgrowth.

Cell Reports | bit.ly/4briiSS

Investigators implemented whole-tissue lineage tracing by 🧬 #genomic DNA barcoding in 3D human 🧠 cerebral #organoids , to show that individual stem cell clones produced progeny on a vastly variable scale.

📖 Nature Cell Biology | go.nature.com/4a5iVR6

Researchers found that 🧠 #neurons expressing SATB2, a determinant of callosal projection neuron (CPN) identity, show impaired maturation in ARID1B+/− neural #organoids .

📖 Cell Stem Cell | bit.ly/3QAkn6Y

Investigators assessed the multifaceted 💬 interactions between palmitic acid, cell proliferation, and the intestinal epithelial barrier using a 🐕 canine colonoid model, as they offer a unique platform to explore mechanisms of #intestinal dysfunction.

👉 bit.ly/3UwUwhn

The authors provide an overview of recent advancements in 🧫 sebaceous glands (SG) #organoid engineering.

💡 They highlight promising strategies for SG organoid functionalization!

Burns & Trauma | 🔗 bit.ly/4aeM3Fw

Scientists investigated the addition of 🧪 #hyaluronan , a component of the interphotoreceptor matrix, as an additive to promote long-term #organoid survival and enhance 👀 #retinal maturation.

Acta Biomaterialia | bit.ly/3JPYEnR

🔬 Using primary intestinal #organoids and air-liquid interface cultures of airway epithelia, scientists demonstrated that the 🧬 F508del mutation in ferret #CFTR results in a severe folding and trafficking defect.

📖 JCI insight | bit.ly/44sFG07

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bit.ly/3WosY0a

The authors outline key developments in the 🧫 induced pluripotent stem cell ( #iPSC ) field and highlight the immense versatility of the iPSC technology for modeling and 💊 therapeutic applications.

Signal Transduction and Targeted Therapy(STTT) | 🔗 go.nature.com/3JJNpgI

Colorectal cancer (CRC) cell xenografts, 🧫 patient-derived xenografts, patient-derived #organoids , and orthotopic #metastasis 🐭 mouse models were utilized to determine the role of SF3B3 in CRC progression and metastasis.

🔗 bit.ly/4aYYarx

Scientists replicated #corticogenesis in the #Huntington 's disease (HD) fetal brain using patient-derived 🧠 cortical #organoids .

The organoids had pathological phenotypes, including abnormalities in early HD subcortical projections.

molecularpsychiatry | go.nature.com/3wg7Xdu

Using #ColorectalCancer patient-derived #organoids , investigators found that compared to LGR5- cells, LGR5+ #cancer stem cells were stiffer, adhered better to the 🧫 extracellular matrix, and formed larger transendothelial gaps!

📖 Nature Communications | go.nature.com/4a4MQbY

Bioprinted scaffolds facilitated the long-term cultivation and progressive maturation of extensive bioprinted 🦴 bone #organoids , fostered multicellular differentiation, and offered valuable 💡 insights into the initial stages of #bone formation.

🔗 bit.ly/3Qd1Z41