Scientists studied the role of intestinal epithelial 🧬 DNA methylation in #Crohn 's disease (CD) pathogenesis.

They generated intestinal 🧫 #organoids from mucosal biopsies of patients with CD, #UlcerativeColitis , and healthy controls.

Gut Journal | bit.ly/3KLydju

🔎 Investigators comprehensively characterized the morphological, molecular, and metabolic responses of porcine endometrial 🧫 #organoids to bisphenol A and assessed the potential protective effects of #melatonin and resveratrol.

🔗 bit.ly/4ciMpN0

Scientists induced and characterized an 🌡️ #inflammation -mediated #fibrosis in patient-derived #organoids issued from crypts isolated from colonic mucosal biopsies of #IBD 👶 pediatric patients and age-matched-control subjects.

Sapienza Università di Roma | 👉 bit.ly/3VCnD4E

Excited to share new work from our lab and @versp1 led by Melissa Cadena! We're always thinking of ways to improve and customize organoid culture and differentiation. So we turned to 3D bioprinting to build tunable scaffolds for cortical organoids. bit.ly/3x9nI6G

Researchers generated 🧠 hindbrain #organoids containing serotonergic #neurons using #hiPSCs .

They lay the groundwork for using hindbrain organoids to evaluate individual differences in disease progression and 💉 treatment response.

molecularpsychiatry | 🔗 go.nature.com/4bVC09W

Authors from Columbia University review the application of 🧠 brain #organoids in neural disorder modeling and emerging #bioengineering methods to improve data 📊 collection and feature extraction at multiscale.

📖 #review | bit.ly/4bVawRT

🔬 Scientists observed morphological changes in normal liver tissue in mouse liver #organoids with ➕ positive albumin expression and potential for differentiation toward #hepatocyte -like cells.

🔗 bit.ly/3VtAXIH

💊 Cetuximab treatment overcame tumor resistance to fulvestrant and abemaciclib in FAR and EGFR-overexpressing breast cancer #spheroids and xenografts!

Check it out! 👉 bit.ly/3KzQ6Sk

💌 The Science News Program by STEMCELL Technologies offers 20 free weekly newsletters in various fields of 🔬 cell biology and #immunology , allowing you to pick and choose your science news.

Visit today to get started! 👉 bit.ly/3IqsZIV

Scientists developed a multifunctional 💻 #microfluidic chip to perform all procedures of organoid-based 💊 drug response tests, including establishment, culturing, drug treatment, and #ATP monitoring of #organoids .

Analytical Chemistry | bit.ly/3Xdf41G

Researchers enhanced IgA-mediated #neutrophil cytotoxicity against 🧠 neuroblastoma by CD47 blockade!

IgG ch14.18 was converted to the IgA isotype, resulting in potent 🧫 neutrophil-mediated #antibody -dependent cell-mediated cytotoxicity.

Journal for ImmunoTherapy of Cancer | bit.ly/455x1Be

Investigators established 🎥 live-imaging #organoid /peripheral 🩸 blood mononuclear cells co-cultures, introducing OrganoIDNet, a deep-learning-based algorithm, capable of analyzing bright-field images of PDAC organoids acquired with live-cell imaging.

📖 bit.ly/3X8MEG3

Investigators employed 🖨️ 3D bioprinting to generate a high-throughput, tunable, and reproducible scaffold for controlling #organoid development and patterning.

👉 bit.ly/4bNzXVu

To generate the liver cancer #organoids , HUH-7 #hepatoma cells were cultured alone or with human 🦴 bone marrow-derived #mesenchymal stromal cells and human umbilical vein endothelial cells in plasma-rich platelet 🧫 #ExtracellularMatrix .

🔗 bit.ly/3VaWxAt

📖 The methods for establishing cartilage #organoids are summarized and an overview of the advantages and limitations of using 🧪 #matrigel in the cultivation of such organoids is provided.

👉 bit.ly/3wJyXTe

Investigators focused on patients with advanced EGFR-mutated #NSCLC and employed a cancer 🧫 #organoid -based diagnosis reactivity prediction-based precision oncology platform to assess the efficacy of EGFR ⛔ inhibitor treatments.

npj Journals | go.nature.com/3X2vfOY

🔎 Investigators presented a novel composite bioink for culturing #colorectal cancer #organoids that provided an environment close to real tissue growth conditions and exhibited 🧪 photocrosslinking properties for rapid gel formation.

BF | bit.ly/3R6yjpG

🔎 To explore Wilms tumor-1 (WT1)-mediated transcriptional #regulation during podocyte development, patient-derived kidney #organoids derived from a patient with a heterozygous missense 🧬 mutation in WT1 were generated.

👉 bit.ly/3R9BgFX

Congrats to Dr. Shiming Chen! She has received a Seed grant from WashU Center of Reg Med for her project, “hiPSC-induced retinal organoids modeling CRX-linked retinopathies.” This research aims to create 3D retinal organoids to model inherited retinal diseases.
ophthalmology.wustl.edu/hipsc-retinal-…