2/After 50 years of adjuvant trials on RCC (3 slides); #KEYNOTE564 demonstrates overall survival (OS) benefit!

1/ The long-awaited OS results from #KEYNOTE -564 are out NEJM! The 1st phase 3 trial to demonstrate a survival benefit for adjuvant treatment in #RCC .

nejm.org/doi/full/10.10…

1/ Thrilled to share that our paper “Impact of RCC molecular subtypes on immunotherapy & targeted therapy outcomes” is now published in Cancer Cell
Collaborative effort co-led w/ Chris Labaki & Tejas Jammihal under Eli Van Allen Sachet Ashok Shukla Toni Choueiri, MD David Braun ‘s mentorship…

Our notifications are blowing up with basketball tweets, but we are the Yale molecular biophysics and biochemistry account! You might want to tag Yale Men's Basketball instead 🏀

Boola boola!

Dr. Srinivas Viswanathan (Srinivas Viswanathan) Dana-Farber is studying mechanisms and sex differences in #KidneyCancer . viswanathanlab.dana-farber.org #KidneyCancer AwarenessMonth

Today, NEJM published our clinical study of a novel #CARTCell in patients with #Glioblastoma . Early results with CARv3-TEAM-E suggest safety and bioactivity. Special thanks to all collaborators MGH Neurosurgery and Mass General Cancer Center!
nej.md/3VnjUIq

March is Kidney Cancer Awareness Month. Our researcher, Dr. Srinivas Viswanathan, is changing the game with his work for kidney cancer research. 👇

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… Bo Xia

Congratulations to Gopi, Payal Kapur and all authors on developing tRCC model UTSW Simmons Cancer Center and thanks to all the #kidneycancer KidneyCancerProgram patients that contributed as well as CPRIT, Joey's Wings Foundation, Plano Pacers and Dallas DASH that made this possible. jci.org/articles/view/…

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Today I'm happy to share our work on tumor karyotype selection, explored experimentally in Stephen Elledge's lab!

nature.com/articles/s4158…

cool work from Tim Pollex Eileen Furlong and colleagues showing that 3D chromatin loops support cross regulation between pairs of paralogs doi.org/10.1016/j.molc…

Very grateful to Damon Runyon Cancer Research Foundation for continued support of our lab's work on X-chromosome alterations and sex bias in cancer.

Excited to share the latest #MsaouelLab collaborative effort in Nature Communications characterizing #SMARCB1 deficiency as a driver of urothelial carcinoma subsets at least in part via IL6/JAK/STAT signaling 👉nature.com/articles/s4146…

Proudly presenting our new findings on how #RNA binding proteins (RBPs) may increase the tolerance of genomes to transposable element (TE) insertions. If you want to know more read this thread or our story nature
nature.com/articles/s4158…

Happy groundhog day! Enjoyed this comprehensive groundhog prediction analysis: journals.ametsoc.org/view/journals/… : 'this study determined, without a shadow of a doubt, that groundhog prognosticating abilities for the arrival of spring are no better than chance'

Proud to present SHIFTR, a novel platform for region-specific RNA interactome discovery developed by fantastic PhD student Jens Aydin 👨‍🔬 in my group, now published in Nucleic Acids Res:
1/8

academic.oup.com/nar/advance-ar…

There comes a time in a PIs life where they rip free of the chains that bind them, and simply say all the things they want to say about a great paper. So here we go, a new paper driven by Mahnoor M and led by Payam A. Gammage and I: nature.com/articles/s4301… Prepare to be annoyed

And now the final version Nature Cancer! 🥳 rdcu.be/dxcnr

Some updates... 1/6

tldr; mtDNA mutations, found in ~50% of all cancers, are immunomodulatory - we can mimic the effect to make non-mtDNA mutant cancer sensitive to immunotherapy drugs.

NEW PAPER👇
How do microproteins orchestra cancer?
Check it out and see for some nifty work in #medulloblastoma .

So proud of Damon Hofman J Ruiz Orera and Sebastiaan van Heesch for collaboratively leading this work, now out in Molecular Cell

University of Michigan Michigan Medicine U-M Rogel Cancer Center UMich RNA Center

Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. biorxiv.org/content/10.110…